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Titolo: RAPID DIAGNOSIS OF EARLY ECTOPIC PREGNANCY IN AN EMERGENCY GYNECOLOGYSERVICE - ARE MEASUREMENTS OF PROGESTERONE, INTACT AND FREE BETA-HUMAN CHORIONIC-GONADOTROPIN HELPFUL
Autore: LEDGER WL; SWEETING VM; CHATTERJEE S;
- Indirizzi:
- JOHN RADCLIFFE HOSP,NUFFIELD DEPT OBSTET & GYNAECOL OXFORD OX3 9DU ENGLAND CTR REPROD BIOL,DEPT OBSTET & GYNAECOL EDINBURGH EH3 9EW SCOTLAND CTR REPROD BIOL,REPROD ENDOCRINE LAB EDINBURGH EH3 9EW SCOTLAND
- Titolo Testata:
- Human reproduction
fascicolo: 1,
volume: 9,
anno: 1994,
pagine: 157 - 160
- SICI:
- 0268-1161(1994)9:1<157:RDOEEP>2.0.ZU;2-P
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- HCG; SERUM; ASSAYS; AID;
- Keywords:
- BIOCHEMICAL MARKER; ECTOPIC PREGNANCY; HCG; ULTRASONOGRAPHY;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 28
- Recensione:
- Indirizzi per estratti:
-
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- Citazione:
- W.L. Ledger et al., "RAPID DIAGNOSIS OF EARLY ECTOPIC PREGNANCY IN AN EMERGENCY GYNECOLOGYSERVICE - ARE MEASUREMENTS OF PROGESTERONE, INTACT AND FREE BETA-HUMAN CHORIONIC-GONADOTROPIN HELPFUL", Human reproduction, 9(1), 1994, pp. 157-160
Abstract
The clinical usefulness of measuring serum concentrations of progesterone, human chorionic gonadotrophin (HCG) and the free beta-subunit ofHCG in distinguishing between early viable and non-viable pregnancy, before an accurate ultrasound diagnosis is possible, was evaluated in a prospective study of patients presenting to our emergency gynaecology service with a clinical suspicion of ectopic pregnancy. Patients were selected on the basis of initial HCG concentrations; samples with HCG 25-10 000 IU/l were later analysed for progesterone and free beta HCG. Of the 181 patients studied, 38 (21%) had an ectopic pregnancy, 108(60%) had a spontaneous abortion and 35 (19%) had a viable intra-uterine pregnancy. Concentrations of HCG and free beta HCG in the group with viable pregnancies were significantly higher than in the group withectopic pregnancy (P < 0.001) and than those destined to miscarry (P < 0.01). Progesterone concentrations were also significantly higher inthe viable versus the ectopic and the spontaneous abortion groups (P < 0.001 in each case). Despite these highly significant differences there was a degree of overlap such that it was impossible to devise a cut-off level for any hormone analysed, either singly or in combination,which would offer a clinically useful predictor of outcome.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:56:35