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Titolo:
IMMUNOHISTOCHEMICAL LOCALIZATION OF 17-ALPHA-HYDROXYLASE C17-20 LYASEAND AROMATASE CYTOCHROME-P-450 IN POLYCYSTIC HUMAN OVARIES/
Autore:
TAMURA T; KITAWAKI J; YAMAMOTO T; OSAWA Y; KOMINAMI S; TAKEMORI S; OKADA H;
Indirizzi:
KYOTO PREFECTURAL UNIV MED,DEPT OBSTET & GYNECOL,KAMIKYO KU,KAWARAMACHI HIROKOJI KYOTO KYOTO 602 JAPAN KYOTO PREFECTURAL UNIV MED,DEPT OBSTET & GYNECOL,KAMIKYO KU KYOTO KYOTO 602 JAPAN MED FDN BUFFALO INC,RES INST,DEPT ENDOCRINE BIOCHEM BUFFALO NY 14203 HIROSHIMA UNIV,FAC INTERGRATED ARTS & SCI HIGASHIHIROSHIMA 724 JAPAN
Titolo Testata:
Journal of Endocrinology
fascicolo: 3, volume: 139, anno: 1993,
pagine: 503 -
SICI:
0022-0795(1993)139:3<503:ILO1CL>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRANULOSA-CELLS; WOMEN; ESTRADIOL; DISEASE; PURIFICATION; ESTROGENS; ANDROGENS; MECHANISM; FOLLICLES; CLEAVAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
T. Tamura et al., "IMMUNOHISTOCHEMICAL LOCALIZATION OF 17-ALPHA-HYDROXYLASE C17-20 LYASEAND AROMATASE CYTOCHROME-P-450 IN POLYCYSTIC HUMAN OVARIES/", Journal of Endocrinology, 139(3), 1993, pp. 503

Abstract

Immunohistochemical localization of 17 alpha-hydroxylase/C17-20 lyase(P-450(17 alpha,lysase)) and aromatase cytochrome P-450 (P-450(arom))in polycystic ovary (PCO) syndrome was studied using specific polyclonal antibodies which had been raised against the corresponding enzymes. In the majority of follicles that were atretic and smaller than 7 mmin diameter, theca interna cells showed high P-450(17 alpha,lyase) immunoreaction, while small numbers of granulosa cells showed little P-450(arom) immunoreaction. In some atretic follicles that were larger than 11 mm in diameter, the hyperplastic theca interna cell layer showedhigh immunoreaction to P-450(17 alpha,lyase), while the poorly proliferated granulosa cell layer showed a mixture of weak and negative immunoreaction to P-450(arom). No immunoreaction to P-450(17 alpha,lyase) or P-450(arom) was recognized in PCO stroma. These findings suggest that the theca interna cells and the granulosa cells from PCOs show abnormal steroidogenic function, while the localization of P-450(17 alpha,lyase) and P-450(arom) in PCOs was essentially identical to that in the normal ovary. Theca interna cells in PCO atretic follicles are the main site of excess androgen production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:16:20