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Titolo:
THE VAGUS NERVE AND ITS NONCHOLINERGIC MECHANISM IN THE MODULATION OFETHANOL-INDUCED GASTRIC-MUCOSAL DAMAGE IN RATS
Autore:
KO JKS; CHO CH; OGLE CW;
Indirizzi:
UNIV HONG KONG,FAC MED,DEPT PHARMACOL HONG KONG HONG KONG
Titolo Testata:
Journal of Pharmacy and Pharmacology
fascicolo: 1, volume: 46, anno: 1994,
pagine: 29 - 33
SICI:
0022-3573(1994)46:1<29:TVNAIN>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW; CYTOPROTECTION; PIRENZEPINE; PROTECTION; SECRETION; VAGOTOMY; NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
J.K.S. Ko et al., "THE VAGUS NERVE AND ITS NONCHOLINERGIC MECHANISM IN THE MODULATION OFETHANOL-INDUCED GASTRIC-MUCOSAL DAMAGE IN RATS", Journal of Pharmacy and Pharmacology, 46(1), 1994, pp. 29-33

Abstract

The role of the cholinergic pathway in the vagus nerve in modulating gastric lesion formation by ethanol was examined, using an ex-vivo stomach chamber preparation. Subdiaphragmatic vagotomy significantly increased the lesion areas but lowered acid secretion and gastric mucosal blood flow (GMBF). Atropine had no effect, whereas pirenzepine antagonized ethanol-induced mucosal damage. All three procedures showed similar potencies in depressing acid secretion, but only pirenzepine reversed the fall in the GMBF produced by ethanol. These differential effects of vagotomy, atropine and pirenzepine on gastric function suggest that the cholinergic component in the vagus nerve may not be important in the formation of ethanol-induced gastric damage. The persistent protective action as well as the restoration of ethanol-induced GMBF drop by pirenzepine in vagotomized animals further support this hypothesis. The worsening effect of vagotomy is probably modulated by a non-cholinergic mechanism, the abolition of which makes the gastric mucosa moresusceptible to damage by ethanol. The acid-independent protective action of pirenzepine and its influence on the GMBF, which were not exhibited by atropine, are indeed unique and perhaps may be attributed to this non-cholinergic pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 22:01:32