Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PEPTIDERGIC PATHWAY IN HUMAN SKIN AND RAT PERITONEAL MAST-CELL ACTIVATION
Autore:
MOUSLI M; HUGLI TE; LANDRY Y; BRONNER C;
Indirizzi:
UNIV LOUIS PASTEUR STRASBOURG 1,INSERM,CJF 9105,NEUROIMMUNOPHARMACOL LAB,BP 24 F-67401 ILLKIRCH GRAFFENS FRANCE SCRIPPS CLIN & RES INST,DEPT IMMUNOL LA JOLLA CA 92037
Titolo Testata:
Immunopharmacology
fascicolo: 1, volume: 27, anno: 1994,
pagine: 1 - 11
SICI:
0162-3109(1994)27:1<1:PPIHSA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GTP-BINDING PROTEINS; HISTAMINE-RELEASE; SUBSTANCE-P; DEGRANULATING PEPTIDE; BENZALKONIUM CHLORIDE; PERTUSSIS TOXIN; PLASMA-MEMBRANE; VENOM PEPTIDES; COMPOUND 48/80; CALCIUM ENTRY;
Keywords:
MAST CELL ACTIVATION; IGE RECEPTOR; CATIONIC SECRETAGOGUE; G PROTEIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
M. Mousli et al., "PEPTIDERGIC PATHWAY IN HUMAN SKIN AND RAT PERITONEAL MAST-CELL ACTIVATION", Immunopharmacology, 27(1), 1994, pp. 1-11

Abstract

The common pathway of heterogenous mast cell activation as mediated by antigens is through the cross-linking of IgE bound to Fc epsilon RI receptors. The peptidergic pathway of mast cell activation, achieved by cationic secretagogues, is restricted to ''serosal'' mast cells, theexperimental models being rat peritoneal and human skin mast cells. Cationic secretagogues include positively charged peptides but also various amines such as compound 48/80 and natural polyamines. An early intracellular event of this pathway is the activation of pertussis toxin-sensitive G proteins.The correlation observed between the ability of basic compounds to trigger mast cell exocytosis and their potency to activate purified G proteins strongly suggests that cationic compounds activate mast cell G proteins via a receptor-independent but membrane-assisted process. In this paper, alternative mechanisms are discussed. The consequence of G protein stimulation is the activation of phospholipase C with an increase in inositol triphosphates. Natural polyamines are relatively poor triggers of mast cells (10(-4) to 10(-2) M). Neuropeptides such as substance P, neuropeptide Y or vasoactive intestinal peptide, peptidic hormones such as kinins, and venoms such as mastoparan and mast cell degranulating peptide, are all active in a concentration range from 10(-7) to 10(-4) M. The cationic anaphylatoxin C3a also stimulates mast cells at concentrations below precursor complement C3 blood levels. The component C3 of the complement system is one of only a few plasma proteins having activation fragments (i.e. C3a) that can be generated at micromolar levels. The effects of basic secretagogues defines a peptidergic pathway of mast cell activation, which represents a potentially toxic process considering the tissue effects caused by exogenous basic compounds such as venom peptides and certain amine containing drugs. Peptidergic activation of mast cells may also be apathophysiological process having an important role in neurogenic inflammation and in diseases involving extensive activation of the blood complement cascade.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 09:57:19