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Titolo:
ROLE FOR THE STEM-CELL FACTOR KIT COMPLEX IN SCHWANN-CELL NEOPLASIA AND MAST-CELL PROLIFERATION-ASSOCIATED WITH NEUROFIBROMATOSIS/
Autore:
RYAN JJ; KLEIN KA; NEUBERGER TJ; LEFTWICH JA; WESTIN EH; KAUMA S; FLETCHER JA; DEVRIES GH; HUFF TF;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT MICROBIOL & IMMUNOL,BOX 980678 MCV STN RICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT MICROBIOL & IMMUNOLRICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT HUMAN GENET RICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT BIOCHEM & MOLEC BIOPHYS RICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT OBSTET & GYNECOL RICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DIV HEMATOL & ONCOL RICHMOND VA 23298 BRIGHAM & WOMENS HOSP,DEPT PATHOL BOSTON MA 02115 DANA FARBER CANC INST,DEPT PEDIAT ONCOL BOSTON MA 00000 CHILDRENS HOSP,DIV HEMATOL ONCOL BOSTON MA 00000 HARVARD UNIV,SCH MED,DEPT PATHOL BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT PEDIAT BOSTON MA 02115
Titolo Testata:
Journal of neuroscience research
fascicolo: 3, volume: 37, anno: 1994,
pagine: 415 - 432
SICI:
0360-4012(1994)37:3<415:RFTSFK>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-KIT RECEPTOR; GTPASE ACTIVATING PROTEIN; GROWTH-FACTOR; PERIPHERAL-NERVE; TYROSINE-PHOSPHORYLATION; SACCHAROMYCES-CEREVISIAE; COMMITTED PROGENITOR; GENE-PRODUCT; CDNA CLONES; RAS GTPASE;
Keywords:
SCHWANN CELL; MAST CELL; NEUROFIBROMATOSIS; STEM CELL FACTOR; KIT; ONCOGENE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
71
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Ryan et al., "ROLE FOR THE STEM-CELL FACTOR KIT COMPLEX IN SCHWANN-CELL NEOPLASIA AND MAST-CELL PROLIFERATION-ASSOCIATED WITH NEUROFIBROMATOSIS/", Journal of neuroscience research, 37(3), 1994, pp. 415-432

Abstract

Schwann cells are the primary cell type in the disfiguring lesions associated with neurofibromatosis type 1 (NF-1). These lesions also contain abnormally high numbers of mast cells, a cell type which develops in response to stem cell factor. We report here that neonatal and adult rat and human Schwann cells, as well as a transfected rat Schwann cell line and a human Schwannoma line derived from an NF-1 patient, all produced stem cell factor mRNA and protein. In coculture experiments, surface expression of stem cell factor by neonatal rat Schwann cells was profoundly downregulated by contact with dorsal root ganglion neurites. The receptor for stem cell factor, KIT, was not expressed in normal Schwann cells but was expressed in the human Schwannoma line, suggesting that aberrant KIT expression may form an autocrine loop in certain Schwann cell neoplasias. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:36:25