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Titolo:
PHYSIOLOGICAL EVIDENCE FOR IPSILATERAL INHIBITION IN THE LATERAL SUPERIOR OLIVE - SYNAPTIC RESPONSES IN MOUSE-BRAIN SLICE
Autore:
WU SH; KELLY JB;
Indirizzi:
CARLETON UNIV,DEPT PSYCHOL,SENSORY NEUROSCI LAB,329 LIFE SCI BLDG,1125 COLONEL BY DR OTTAWA K1S 5B6 ON CANADA CARLETON UNIV,DEPT PSYCHOL,SENSORY NEUROSCI LAB OTTAWA K1S 5B6 ON CANADA
Titolo Testata:
Hearing research
fascicolo: 1, volume: 73, anno: 1994,
pagine: 57 - 64
SICI:
0378-5955(1994)73:1<57:PEFIII>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTEROVENTRAL COCHLEAR NUCLEUS; UNIT EXCITATORY RESPONSES; SINGLE AUDITORY UNITS; BINAURAL TONE BURSTS; BUSHY CELL AXONS; TRAPEZOID BODY; MEDIAL NUCLEUS; GUINEA-PIG; GLYCINE IMMUNOREACTIVITY; HORSERADISH-PEROXIDASE;
Keywords:
BINAURAL INTERACTION; SOUND LOCALIZATION; TRAPEZOID BODY; SUPERIOR OLIVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
S.H. Wu e J.B. Kelly, "PHYSIOLOGICAL EVIDENCE FOR IPSILATERAL INHIBITION IN THE LATERAL SUPERIOR OLIVE - SYNAPTIC RESPONSES IN MOUSE-BRAIN SLICE", Hearing research, 73(1), 1994, pp. 57-64

Abstract

The incidence of ipsilateral inhibition in the lateral superior olive(LSO) was examined in a brain slice preparation of the mouse superiorolivary complex. A 400 mu m brain slice was taken in the frontal plane and maintained in a warm, oxygenated saline solution. Intracellular recordings were made from the LSO with micropipettes filled with 4 M potassium acetate. Synaptic responses were elicited by electrical stimulation of the trapezoid body in different slices at various locations between the cochlear nucleus and the ipsilateral superior olivary complex (SOC). The results show that ipsilateral stimulation can evoke inhibitory as well as excitatory postsynaptic potentials. The ipsilateralIPSPs have short latencies and are elicited by stimulation of the trapezoid body at any point along its course between cochlear nucleus andLSO. Short-latency IPSPs can also be produced by direct stimulation of the ventral cochlear nucleus itself. Ipsilateral IPSPs are blocked by low concentrations of the glycine antagonist, strychnine. In addition, bath application of sodium pentobarbital in one case eliminated ipsilateral IPSPs without eliminating EPSPs. The results suggest that there is a rapidly conducting, glycinergic pathway from cochlear nucleus through the trapezoid body to the LSO on the same side of the brain. This pathway is probably served by either a direct projection from the ventral cochlear nucleus to the LSO or an indirect one from cochlear nucleus to LSO through the lateral nucleus of the trapezoid body (LNTB).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 07:11:30