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Titolo:
EFFECT OF CONTINUOUS POSITIVE AIRWAY PRESSURE TREATMENT ON DAYTIME FUNCTION IN SLEEP APNOEA HYPOPNOEA SYNDROME/
Autore:
ENGLEMAN HM; MARTIN SE; DEARY IJ; DOUGLAS NJ;
Indirizzi:
CITY HOSP,RESP MED UNIT,GREENBANK DR EDINBURGH EH10 5SB MIDLOTHIAN SCOTLAND UNIV EDINBURGH,DEPT MED,RESP MED UNIT EDINBURGH MIDLOTHIAN SCOTLAND UNIV EDINBURGH,DEPT PSYCHOL EDINBURGH MIDLOTHIAN SCOTLAND
Titolo Testata:
Lancet
fascicolo: 8897, volume: 343, anno: 1994,
pagine: 572 - 575
SICI:
0140-6736(1994)343:8897<572:EOCPAP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
APNEA HYPOPNEA SYNDROME; PERFORMANCE; DEPRESSION; HEALTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
H.M. Engleman et al., "EFFECT OF CONTINUOUS POSITIVE AIRWAY PRESSURE TREATMENT ON DAYTIME FUNCTION IN SLEEP APNOEA HYPOPNOEA SYNDROME/", Lancet, 343(8897), 1994, pp. 572-575

Abstract

Continuous positive airway pressure (CPAP) is the treatment of choicefor the sleep apnoea/hypopnoea syndrome (SAHS); it is usually given with the aim of improving daytime cognitive function, mood, and sleepiness. However, its efficacy has not been validated by controlled trials. We have carried out a randomised, placebo-controlled, crossover study of objective daytime sleepiness, symptoms, cognitive function, and mood in a consecutive series of 32 SAHS patients with a median apnoea plus hypopnoea frequency of 28 (range 7-129) per hour slept. Patients were treated with 4 weeks each of CPAP and an oral placebo, which they were told might improve upper airway muscle function during sleep. Assessments on the last day of each treatment included a multiple sleep latency test and tests of symptom scores, mood profiles, and cognitive performance. The patients had significantly less daytime sleepiness onCPAP than during the placebo period (mean sleep latency 7.2 [SE 0.7] vs 6.1 [0.7] min, p = 0.03). There were also improvements with CPAP insymptom ratings (2.1 [0.2] vs 4.3 [0.3], p < 0.001), mood (p < 0.05 for several measures), and cognitive performance, which showed improvedvigilance (obstacles hit in Steer Clear ''driving'' test 76 [5] vs 81[6], p < 0.01), mental flexibility (trail-making B time 66 [5] vs 75 [5] vs p < 0.05), and attention (p < 0.05). Objectively monitored CPAPuse averaged only 3.4 (0.4) hours per night, but this study provides evidence of improved cognitive performance even at this low revel of CPAP compliance.

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Documento generato il 23/01/20 alle ore 18:31:44