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Titolo:
TRANSFER OF A SALT-RESISTANT RENIN ALLELE RAISES BLOOD-PRESSURE IN DAHL SALT-SENSITIVE RATS
Autore:
JIANG J; STEC DE; DRUMMOND H; SIMON JS; KOIKE G; JACOB HJ; ROMAN RJ;
Indirizzi:
MED COLL WISCONSIN,DEPT PHYSIOL,8701 WATERTOWN PLANK RD MILWAUKEE WI 53226 MED COLL WISCONSIN,DEPT PHYSIOL MILWAUKEE WI 53226 MED COLL WISCONSIN,CARDIOVASC RES CTR MILWAUKEE WI 53226 MASSACHUSETTS GEN HOSP,CARDIOVASC RES CTR CHARLESTOWN MA 00000
Titolo Testata:
Hypertension
fascicolo: 2, volume: 29, anno: 1997,
pagine: 619 - 627
SICI:
0194-911X(1997)29:2<619:TOASRA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RAT; CONVERTING ENZYME-INHIBITION; ANGIOTENSIN SYSTEM; GENETIC CONTAMINATION; RENAL PROTECTION; PLASMA-RENIN; LINKAGE MAP; S-RATS; MARKERS; INJURY;
Keywords:
CONGENIC STRAIN; RENIN GENE; GENOTYPE; PHENOTYPE; HYPERTENSION; RENAL FUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
J. Jiang et al., "TRANSFER OF A SALT-RESISTANT RENIN ALLELE RAISES BLOOD-PRESSURE IN DAHL SALT-SENSITIVE RATS", Hypertension, 29(2), 1997, pp. 619-627

Abstract

To evaluate the role of the renin gene in the development of hypertension in Dahl salt-sensitive rats (SS/Jr/Hsd), we derived a congenic strain of rats homozygous for the salt-resistant renin allele (S/ren(ss)) and compared them with a control strain homozygous for the salt-sensitive renin allele (S/ren(ss)). Mean arterial pressure was significantly higher in 12-week-old S/ren(ss) rats fed a high salt (8.0%) diet for 3 weeks than in S/ren(ss) rats or in SS/Jr/Hsd rats rederived from the foundation colony we used to generate the congenic strain (195+/-3 [n=49] versus 168+/-3 [n=17] or 161+/-3 [n=16] mm Hg). Mean arterial pressure was also higher in S/ren(ss) rats than in S/ren(ss) rats raised from birth on either a very low salt (0.1%) diet (119+/-9 [n=6] versus 100+/-7 [n=4] mm Hg) or a low salt (0.4%) diet (143+/-1 [n=22] versus 117+/-3 [n=10] mm Hg). Plasma renin activity of S/ren(ss) rats was significantly higher than that of S/ren(ss) rats fed a very low salt diet (5.7+/-2.0 Versus 1.8+/-0.3 ng angiotensin I/mL per hour), a low salt diet (4.4+/-1.0 Versus 1.1+/-0.3), or a high salt diet (1.5+/-0.2 versus 0.9+/-0.1). Urinary protein excretion was greater in S/ren(ss) rats than in S/ren(ss) rats fed a high salt diet (244.2+/-48.5 versus 43.6+/-19.5 mg/24 h), and this was associated with significant reductions in renal blood flow (3.3+/-0.6 versus 4.6+/-0.5 mL/min per gram kidney weight) and glomerular filtration rate (0.49+/-0.11 versus 0.82+/-0.08 ml/min per gram kidney weight). Captopril (20 mg/kg IV) had no effect on blood pressure in S/ren(ss) rats fed a low salt diet, but it lowered blood pressure by 20 mm Hg in S/ren(ss) rats to the same levelseen in untreated S/ren(ss) rats. Chronic administration of captopril(5 mg/100 mL drinking water) reduced blood pressure in S/ren(ss) ratsfed a high salt diet (170+/-5 mm Hg) to the same level seen in untreated S/ren(ss) rats, whereas it had no significant effect on blood pressure in S/ren(ss) rats. These results indicate that transfer of a salt-resistant renin allele to SS/Jr/Hsd rats raises plasma renin activityand augments the severity of hypertension and renal disease.

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Documento generato il 05/07/20 alle ore 00:16:26