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Titolo:
BRAIN OUABAIN IN THE MEDIAN PREOPTIC NUCLEUS MEDIATES SODIUM-SENSITIVE HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS
Autore:
BUDZIKOWSKI AS; LEENEN FHH;
Indirizzi:
UNIV OTTAWA,INST HEART,HYPERTENS UNIT,40 RUSKIN ST OTTAWA ON K1Y 4E9 CANADA UNIV OTTAWA,INST HEART,HYPERTENS UNIT OTTAWA ON K1Y 4E9 CANADA
Titolo Testata:
Hypertension
fascicolo: 2, volume: 29, anno: 1997,
pagine: 599 - 605
SICI:
0194-911X(1997)29:2<599:BOITMP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-NERVE ACTIVITY; HYPERTONIC NACL; PRESSOR-RESPONSES; FLUID BALANCE; 3RD VENTRICLE; HYPOTHALAMUS; DIGOXIN; NATRIURESIS; VASOPRESSIN; MECHANISMS;
Keywords:
OUABAIN; MEDIAN PREOPTIC NUCLEUS; CENTRAL HYPERTONIC SALINE; SODIUM, DIETARY; RATS, INBRED SHR; AIR STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
A.S. Budzikowski e F.H.H. Leenen, "BRAIN OUABAIN IN THE MEDIAN PREOPTIC NUCLEUS MEDIATES SODIUM-SENSITIVE HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS", Hypertension, 29(2), 1997, pp. 599-605

Abstract

Presser responses to an acute increase in cerebrospinal fluid sodium and exaggeration of the hypertension and sympathetic hyperreactivity in spontaneously hypertensive rats (SI-IR) by high sodium diet involve release of brain ''ouabain'' and subsequent activation of the brain renin-angiotensin system. Tn the present study, we determined whether release of ''ouabain'' in the median preoptic nucleus participates in these responses. In conscious Wistar rats, the presser and heart rate responses to central hypertonic saline (0.3 mol/L NaCl, 3.8 mu L/min over 10 minutes) and ouabain (0.6 mu g) were compared after median preoptic nucleus injection of either gamma-globulins or Fab fragments binding ouabain and brain ''ouabain'' with high affinity. Microinjection of Fab fragments into the median preoptic nucleus abolished the presser and tachycardic responses to central hypertonic saline and significantly reduced the presser response to central ouabain. In SHR on high sodium, microinjection of Fab fragments into the median preoptic nucleus significantly decreased baseline blood pressure to a level not different from that in SHR on regular sodium (149+/-7 Versus 145+/-5 mm Tig), whereas the enhanced responses to air stress were not affected. Our results support the concept that blood pressure responses to central hypertonic saline and exaggeration of the hypertension in SHR by high sodium diet depend on release of brain ''ouabain'' in the median preopticnucleus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:44:50