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Titolo:
THE ESTABLISHMENT OF BILATERAL ASYMMETRY IN SEA-URCHIN EMBRYOS
Autore:
MCCAIN ER; MCCLAY DR;
Indirizzi:
DUKE UNIV,DEPT ZOOL,243 BIOL SCI BLDG,BOX 90325 DURHAM NC 27708
Titolo Testata:
Development
fascicolo: 2, volume: 120, anno: 1994,
pagine: 395 - 404
SICI:
0950-1991(1994)120:2<395:TEOBAI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-ELEGANS EMBRYOS; DORSOVENTRAL AXIS; 1ST CLEAVAGE; HANDEDNESS; REVERSAL;
Keywords:
BILATERAL ASYMMETRY; LEFT/RIGHT AXIS; DORSOVENTRAL AXIS; EMBRYO; CLEAVAGE PATTERN; SEA URCHIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
E.R. Mccain e D.R. Mcclay, "THE ESTABLISHMENT OF BILATERAL ASYMMETRY IN SEA-URCHIN EMBRYOS", Development, 120(2), 1994, pp. 395-404

Abstract

Although much is known about the specification and determination of the two primary axes (animal/vegetal and dorsoventral or oral/aboral) in a number of embryos, little is understood about bilaterality. In thesea urchin, left/right asymmetry is crucial to normal development as the echinus or adult rudiment is positioned on the left side of the larva. We examined the establishment of bilateral asymmetry in Lytechnisvariegatus embryos by determining the relationship of the first cleavage planes to the left/right axis. Embryos were bisected at different times to determine when the bilateral axis is committed. These lineagetracing and cell separation experiments demonstrated that the first cleavage plane divides the embryo into left and right halves, although this is conditional until after late blastula stage. The relationship between the specification of the dorsoventral axis and the bilateral axis was examined experimentally. In other species when the dorsal and ventral halves of early echinoderm embryos (preblastula) are separated, the dorsal half often reverses (180 degrees) its dorsoventral axis. We asked whether those larvae with an inverted dorsoventral axis wouldshift the position of the echinus rudiment from the original left side to the new left side. If so, it would demonstrate that the larval asymmetry is dependent upon specification of the dorsoventral axis. Using a combination of lineage tracing and cell separation techniques, we show that the left/right asymmetry is specified with respect to the dorsoventral axis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 11:10:39