Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECT OF NEW SYNTHETIC CHOLESTEROL DERIVATIVES ON CHOLESTEROL-METABOLISM IN CULTURED RABBIT HEPATOCYTES
Autore:
MAMBETISAEVA ET; KOSYKH VA; MISHARIN AY; KOSENKOV EI; PODREZ EA; REPIN VS;
Indirizzi:
RUSSIAN ACAD MED SCI,CARDIOL RES CTR,INST EXPTL CARDIOL MOSCOW RUSSIA
Titolo Testata:
Biochemistry
fascicolo: 7, volume: 58, anno: 1993,
pagine: 797 - 802
SICI:
0006-2979(1993)58:7<797:EONSCD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY LIPOPROTEIN RECEPTOR; STEROL BIOSYNTHESIS; POLYOXYETHYLATED CHOLESTEROL; OXYGENATED STEROLS; HUMAN-FIBROBLASTS; CELLS; INHIBITION;
Keywords:
SYNTHETIC CHOLESTEROL DERIVATIVES; CHOLESTEROL SYNTHESIS; APOLIPOPROTEIN B SECRETION; BILE ACID PRODUCTION; CULTURED HEPATOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
E.T. Mambetisaeva et al., "EFFECT OF NEW SYNTHETIC CHOLESTEROL DERIVATIVES ON CHOLESTEROL-METABOLISM IN CULTURED RABBIT HEPATOCYTES", Biochemistry, 58(7), 1993, pp. 797-802

Abstract

Effects of three new cholesterol derivatives, 3 beta-(2-aminoethoxy)-5-cholestene (II), 3 beta-(2-azidoethoxy)-5-cholestene (III), and 3 beta-(2-p-toluenesulfonylethoxy)-5-cholestene (IV), on cholesterol synthesis, apolipoprotein B secretion, and bile acid production were studied in cultured rabbit hepatocytes. 3 beta-(2-Hydroxyethoxy)-5-cholestene (I) served as a standard The inhibition of cholesterol synthesis by the investigated compounds was shown to be structure-dependent Compound II showed maximum effect as an inhibitor of sodium [C-14]acetate incorporation into cholesterol (a 30 to 50% inhibition was observed at 1 mu g/ml) but did not influence bile acid production. The effect of compound III was less pronounced, while compound IV failed to inhibit cholesterol synthesis. Incubation of the cells with the investigated compounds caused a 20 to 36% decrease in apolipoprotein B secretion. None of the tested derivatives influenced the overall rate of protein synthesis. The results show that 3 beta-(2-aminoethoxy)-5-cholestene offersthe most promise among the tested compounds with respect to further investigation and development of new cholesterol derivatives capable ofinhibiting both liver cell cholesterol biosynthesis and the secretionof very low density lipoproteins (VLDL).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 19:43:21