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Titolo:
THE ROLE OF FAMILY HISTORY IN RISK OF CHILDHOOD BRAIN-TUMORS
Autore:
GOLD EB; LEVITON A; LOPEZ R; AUSTIN DF; GILLES FH; HEDLEYWHYTE ET; KOLONEL LN; LYON JL; SWANSON GM; WEISS NS; WEST DW; ASCHENBRENER C;
Indirizzi:
UNIV CALIF DAVIS,INST TOXICOL & ENVIRONM HLTH,DIV OCCUPAT & ENVIRONM MED & EPIDEMIOL DAVIS CA 95616 CHILDRENS HOSP BOSTON MA 00000 HARVARD UNIV,SCH MED BOSTON MA 02114 CALIF DEPT HLTH SERV EMERYVILLE CA 00000 CHILDRENS HOSP LOS ANGELES LOS ANGELES CA 90027 UNIV SO CALIF LOS ANGELES CA 00000 MASSACHUSETTS GEN HOSP BOSTON MA 02114 CANC RES CTR HAWAII HONOLULU HI 96813 UNIV UTAH SALT LAKE CITY UT 00000 MICHIGAN STATE UNIV E LANSING MI 48824 UNIV WASHINGTON SEATTLE WA 98195 NO CALIF CANC CTR UNION CITY CA 00000 NEBRASKA MED CTR OMAHA NE 00000
Titolo Testata:
Cancer
fascicolo: 4, volume: 73, anno: 1994,
pagine: 1302 - 1311
SICI:
0008-543X(1994)73:4<1302:TROFHI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER; CHILDREN; EXPOSURE; OCCUPATION; NEOPLASMS; FIELDS; TWINS;
Keywords:
BRAIN TUMORS; CHILDREN; EPIDEMIOLOGY; FAMILIAL; RISK FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
E.B. Gold et al., "THE ROLE OF FAMILY HISTORY IN RISK OF CHILDHOOD BRAIN-TUMORS", Cancer, 73(4), 1994, pp. 1302-1311

Abstract

Background. Although brain tumors are the second most frequent malignancy in children, relatively little is known about the role of family history in risk of these tumors. Methods. Children under the age of 18years (n = 361) in whom primary brain tumors were diagnosed were identified from eight United States population-based Surveillance, Epidemiology, and End Results registries and compared to matched controls (n = 1083) identified by random-digit dialing. Information regarding family history of birth defects or tumors was obtained, along with data onother potential risk factors, from interviews with the mothers and fathers of the index children. Results. No significant differences were found in family history of epilepsy. However, moderate elevations in risk were observed for a history of birth defects in maternal relatives, particularly for female propositi. Significantly more mothers (odds ratio [OR] = 1.63, 95% confidence limits [CL] = 1.03, 2.57) and maternal female relatives (OR = 2.15, 95% CL = 1.14, 4.06) of cases than of controls were reported to have had birth defects. History of birth defects in maternal relatives was particularly associated with childhood brain tumors of ''other'' (not astrocytoma or medulloblastoma) histologic type (OR = 2.37, 95% CL = 1.25, 4.53) and infratentorial tumors (OR = 1.76, 95% CL = 1.06, 2.93). Slight excesses of tumors were observed in paternal relatives of children with astrocytomas (OR = 1.43, 95% CL 0.93, 2.20) or with infratentorial tumors (OR = 1.46, 95% CL 0.97, 2.20). Risk of childhood brain tumors did not increase with the numberof relatives affected with brain tumors, breast cancer, leukemia or lymphoma, soft tissue sarcomas, or all of these tumor types combined (the Li-Fraumeni syndrome). Conclusions. These findings suggest a modestincrease in risk of childhood brain tumors associated with maternal family history of birth defects. Family history of tumors does not appear to contribute appreciably to an increased risk of brain tumors in children.

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Documento generato il 15/07/20 alle ore 08:39:26