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Titolo:
IMMUNOLOGICAL EFFECTS OF ACUTE AND CHRONIC NICOTINE ADMINISTRATION INRATS
Autore:
MCALLISTER CG; CAGGIULA AR; KNOPF S; EPSTEIN LH; MILLER AL; ANTELMAN SM; PERKINS KA;
Indirizzi:
UNIV PITTSBURGH,DEPT PSYCHIAT,BIOMED SCI TOWER W1058,DESOTO & OHARA ST PITTSBURGH PA 15213 PITTSBURGH CANC INST PITTSBURGH PA 00000 UNIV PITTSBURGH,DEPT PSYCHOL PITTSBURGH PA 15260 SUNY BUFFALO,DEPT PSYCHOL BUFFALO NY 14260
Titolo Testata:
Journal of neuroimmunology
fascicolo: 1, volume: 50, anno: 1994,
pagine: 43 - 49
SICI:
0165-5728(1994)50:1<43:IEOAAC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIME-DEPENDENT SENSITIZATION; LYMPHOCYTE-PROLIFERATION; INDUCED MODULATION; CIGARETTE-SMOKING; IMMUNE-RESPONSE; STRESS; SYSTEM; IMMUNOSUPPRESSION; SUPPRESSES; REACTIVITY;
Keywords:
NICOTINE; MITOGENIC RESPONSIVENESS; PERIPHERAL BLOOD LEUKOCYTES; SPLENOCYTES; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
C.G. Mcallister et al., "IMMUNOLOGICAL EFFECTS OF ACUTE AND CHRONIC NICOTINE ADMINISTRATION INRATS", Journal of neuroimmunology, 50(1), 1994, pp. 43-49

Abstract

We previously demonstrated that acute nicotine administration decreased the response of rat blood leukocytes (PBL) to concanavalin A (ConA). We now extend those findings to a comparison between the effects of acute and prolonged nicotine exposure (ten daily injections), on PBL and splenocytes (SL). A single injection suppressed the PBL response toConA and phytohemagglutinin (PHA); tolerance developed by ten injections. In contrast, acute nicotine did not affect SL response to ConA and reduced the PHA response only at the highest concentration. Ten nicotine injections enhanced SL responsiveness to PHA. The only change in PBL subsets was an increase in CD8(+) cells following ten injections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:59:02