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Titolo:
CONSTITUTIVE EXPRESSION OF IMMUNOSUPPRESSION-ASSOCIATED CYTOKINE GENES IN A PANEL OF HUMAN T-LEUKEMIA-CELL LINES - HIGH-INCIDENCE OF TRANSFORMING GROWTH-FACTOR-BETA GENE-EXPRESSION
Autore:
MICALLEF M; ARIYASU T; DAO T; MATSUO Y; MINOWADA J;
Indirizzi:
HAYASHIBARA BIOCHEM LABS INC,FUJISAKI CELL CTR FUJISAKI OKAYAMA 702 JAPAN
Titolo Testata:
International journal of oncology
fascicolo: 3, volume: 4, anno: 1994,
pagine: 633 - 638
SICI:
1019-6439(1994)4:3<633:CEOICG>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-DERIVED CYTOKINES; SUPPRESSOR CELLS; SERUM LEVELS; LYMPHOMA; PROLIFERATION; BEARING; LYMPHOCYTES; INHIBITION; INDUCTION; DISEASE;
Keywords:
T-CELL-LEUKEMIA; IMMUNOSUPPRESSION; TGF-BETA-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M. Micallef et al., "CONSTITUTIVE EXPRESSION OF IMMUNOSUPPRESSION-ASSOCIATED CYTOKINE GENES IN A PANEL OF HUMAN T-LEUKEMIA-CELL LINES - HIGH-INCIDENCE OF TRANSFORMING GROWTH-FACTOR-BETA GENE-EXPRESSION", International journal of oncology, 4(3), 1994, pp. 633-638

Abstract

The expression of RNA for interleukin (IL) -9, -10 and -12, interferon gamma (IFN-gamma), transforming growth factor beta one (TGF-beta1), macrophage inflammatory protein one alpha (MIP-1alpha) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in a panel of human T leukemia cell lines at various stages of differentiation, and normal thymocytes was examined using reverse transcriptase-polymerase chain reaction (RT-PCR). Fourteen of 16 T cell lines expressed the gene for TGF-beta1 and 12 of the cell lines also expressed the gene for GM-CSF. None of the 5 normal thymocyte samples constitutively expressed RNA for TGF-beta1 or GM-CSF. One cell line established from a patient with adult T cell leukemia (ATL), ED-S-, expressed the genes for TGF-beta1, GM-CSF, IL-10, IL-12, IFN-gamma and MIP-1alpha. IL-9 was not expressed by any cell line, IL-10 was expressed by only three cell lines and IL-12 was expressed by only two cell lines. The production of immunosuppressive factors such as TGF-beta1 by T leukemic cells is a possible mechanism for the clinical progression of this disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 16:09:35