Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
LIPID DROPLET ACCUMULATION AND LIPOPROTEIN-LIPASE ACTIVITY IN THE RATSALIVARY-GLAND DURING THE PERINATAL-PERIOD
Autore:
NAGATO T; MASUNO H;
Indirizzi:
EHIME UNIV,SCH MED,DEPT ORAL & MAXILLOFACIAL SURG,454 SHIZUKAWA SHIGENOBU EHIME 79102 JAPAN EHIME UNIV,SCH MED,DEPT MED BIOCHEM SHIGENOBU EHIME 79102 JAPAN
Titolo Testata:
Archives of oral biology
fascicolo: 12, volume: 38, anno: 1993,
pagine: 1127 - 1134
SICI:
0003-9969(1993)38:12<1127:LDAALA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
STREPTOZOTOCIN-DIABETIC RATS; PAROTID ACINAR-CELLS; RADIATION-INJURY; STARVED RATS; MEMBRANES; INSULIN; TRIACYLGLYCEROL; DIFFERENTIATION; ENDOTHELIUM; ADIPOCYTES;
Keywords:
LIPID DROPLET; LIPOPROTEIN LIPASE; SALIVARY GLAND; FETUS; NEWBORN; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
T. Nagato e H. Masuno, "LIPID DROPLET ACCUMULATION AND LIPOPROTEIN-LIPASE ACTIVITY IN THE RATSALIVARY-GLAND DURING THE PERINATAL-PERIOD", Archives of oral biology, 38(12), 1993, pp. 1127-1134

Abstract

The submandibular and sublingual glands of foetal and newborn rats aged 21 days in utero to 7 days after birth were examined morphologically and biochemically. Lipid droplets tended to be localized in secretory cells, especially in their basal cytoplasm. The degree of droplet accumulation varied with the age of the rat. No droplets were observed before and immediately after birth. The number of accumulated droplets peaked 26-48 h after birth, then gradually decreased and reached normal levels by 5 days. In the salivary glands of fasted newborn rats, no lipid droplets were observed throughout the experiment. The amount of triacylglycerol reached its maximum level 1 day after birth; it then decreased gradually until 5 days and after that did not change. The amount of cholesterol did not change during postnatal development. Lipaseactivity attained its maximum level in the salivary glands immediately after birth and then decreased rapidly. It was higher in the glands of fasted than fed 1-day-old rats. Antiserum against lipoprotein lipase inhibited the salivary gland lipase activity in a dose-dependent manner, with 5 mu l of antiserum producing 60-70% inhibition. Non-immune serum had little effect. It was concluded that (1) accumulated lipid in the secretory cell cytoplasm of the salivary glands originates from ingested milk; (2) the principal component of accumulated lipid droplets is triacylglycerol; (3) 60-70% of the total lipase activity represents lipoprotein lipase; (4) an increase of lipoprotein lipase activityis recognizable before the accumulation of triacylglycerol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 02:04:24