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Titolo:
AUTORADIOGRAPHIC IMAGING OF CEREBRAL-ISCHEMIA USING A COMBINATION OF BLOOD-FLOW AND HYPOXIC MARKERS IN AN ANIMAL MODAL
Autore:
LYTHGOE MF; WILLIAMS SR; WIEBE LI; MCEWAN AJB; GORDON I;
Indirizzi:
ROYAL COLL SURGEONS ENGLAND,INST CHILD HLTH,BIOPHYS UNIT,30 GUILFORD ST LONDON WC1N 1EH ENGLAND GREAT ORMOND ST HOSP CHILDREN NHS TRUST,DEPT RADIOL LONDON WC1N 3JH ENGLAND UNIV ALBERTA EDMONTON AB T6G 2M7 CANADA
Titolo Testata:
European journal of nuclear medicine
fascicolo: 1, volume: 24, anno: 1997,
pagine: 16 - 20
SICI:
0340-6997(1997)24:1<16:AIOCUA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC PENUMBRA; TISSUE HYPOXIA; FOCAL ISCHEMIA; RATS; INFARCTION; THRESHOLDS; THERAPY; STROKE;
Keywords:
IODOAZOMYCIN ARABINOSIDE; HEXAMETHYLPROPYLENE AMINE OXIME; HYPOXIA; PENUMBRA; STROKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M.F. Lythgoe et al., "AUTORADIOGRAPHIC IMAGING OF CEREBRAL-ISCHEMIA USING A COMBINATION OF BLOOD-FLOW AND HYPOXIC MARKERS IN AN ANIMAL MODAL", European journal of nuclear medicine, 24(1), 1997, pp. 16-20

Abstract

Current routine clinical techniques, including angiography and perfusional single-photon emission tomography, can be used to indicate problems in cerebral vascular supply and areas of cerebral hypoperfusion following a stroke, but cannot distinguish between ischaemic core and penumbra. In order to image specifically the penumbra, a method or indicator should be able to define areas with reduced blood flow, and a degree of metabolic compromise. In this context, the tissue could be regarded as hypoxic rather than ischaemic, and we have therefore chosen toinvestigate the potential of radio-labelled hypoxic markers in the study of ischaemia. In order to combine a hypoxic marker with a blood flow marker we used technetium-99m hexamethylpropylene amine oxime (Tc-99m-HMPAO) and iodine-125 iodoazomycin arabinoside (I-125-IAZA), duringcerebral ischaemia in the rat middle cerebral artery occlusion model. Tc-99m-HMPAO and I-125-IAZA were injected simultaneously 2 h following occlusion of the middle cerebral artery, and 5 h before decapitation. Paired autoradiograms were produced and compared. Three distinct patterns emerged from the autoradiograms: slightly decreased perfusion with no uptake of the hypoxic marker indicating an area of misery perfusion; moderately decreased perfusion with concomitant uptake of iodoazomycin arabinoside, a region of hypoxia; and severely decreased perfusion with no retention of the hypoxic tracer. In conclusion, we present a new use for an imaging agent in the investigation of cerebral hypoxia. This agent, IAZA together with HMPAO, provides a means of separating the penumbra into regions of misery perfusion and hypoxia. The potential impact of this may be important in the clinical investigation of stroke.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:30:41