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Titolo:
INTERLEUKIN-12
Autore:
BRUNDA MJ;
Indirizzi:
HOFFMANN LA ROCHE INC,DEPT ONCOL NUTLEY NJ 07110
Titolo Testata:
Journal of leukocyte biology
fascicolo: 2, volume: 55, anno: 1994,
pagine: 280 - 288
SICI:
0741-5400(1994)55:2<280:I>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL STIMULATORY FACTOR; NATURAL-KILLER-CELL; LYMPHOCYTE MATURATION FACTOR; ACTIVATED HUMAN LYMPHOBLASTS; T RESPONSES INVITRO; INTERFERON-GAMMA; FACTOR NKSF; MURINE LEISHMANIASIS; IFN-GAMMA; RECOMBINANT INTERLEUKIN-2;
Keywords:
ANTITUMOR; CYTOKINE; CYTOLYSIS; INTERFERON GAMMA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Brunda, "INTERLEUKIN-12", Journal of leukocyte biology, 55(2), 1994, pp. 280-288

Abstract

Interleukin-12 (IL-12) is a newly characterized cytokine that has a unique heterodimeric structure. It was initially cloned from B lymphoblastoid cell lines, but the majority of IL-12 is produced by macrophages/monocytes following; appropriate stimulation. IL-12 can (1) enhance the cytolytic activity of a number of effector cells including T cells, natural killer (NK) cells, lymphokine activated killer (LAK) cells, and macrophages, (2) increase proliferation of activated NK and T cells, (3) induce production of cytokines, such as interferon gamma, (4) stimulate the induction of T(H)1 cells, (5) upregulate a number of cellsurface molecules, (6) inhibit IgE secretion, and (7) act as a synergistic factor for hematopoietic stem cells. Based on these potent immunomodulatory activities, IL-12 has been evaluated in several disease models for parasitic infections and malignancies. Marked activity of IL-12 against both Leishmania and Toxoplasma has been reported. Likewise,antimetastatic and antitumor activity, including tumor regression, has been observed against a number of murine malignancies treated with IL-12 using doses that result in little toxicity. The results suggest that IL-12 may be a useful cytokine for the treatment of a number of diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:44:13