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Titolo:
THE ROLE OF TYROSINE KINASES AND PHOSPHOTYROSINE-CONTAINING RECOGNITION MOTIFS IN REGULATION OF THE T-CELL-ANTIGEN RECEPTOR-MEDIATED SIGNAL-TRANSDUCTION PATHWAY
Autore:
ISAKOV N; WANGE RL; SAMELSON LE;
Indirizzi:
NICHHD,CELL BIOL & METAB BRANCH,BLDG 18T,ROOM 101 BETHESDA MD 20892 BEN GURION UNIV NEGEV,CANC RES CTR BEER SHEVA ISRAEL BEN GURION UNIV NEGEV,FAC HLTH SCI,DEPT MICROBIOL & IMMUNOL IL-84105 BEER SHEVA ISRAEL
Titolo Testata:
Journal of leukocyte biology
fascicolo: 2, volume: 55, anno: 1994,
pagine: 265 - 271
SICI:
0741-5400(1994)55:2<265:TROTKA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-TERMINAL DOMAIN; PROTEIN-KINASE; ZETA-CHAIN; C-SRC; PHOSPHOLIPASE C-GAMMA-1; CYTOPLASMIC TAIL; MOLECULAR-CLONING; CROSS-LINKING; BINDING-SITE; CD4 RECEPTOR;
Keywords:
SH2; SH3; TAM; TYROSINE PHOSPHORYLATION; T CELL ACTIVATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
94
Recensione:
Indirizzi per estratti:
Citazione:
N. Isakov et al., "THE ROLE OF TYROSINE KINASES AND PHOSPHOTYROSINE-CONTAINING RECOGNITION MOTIFS IN REGULATION OF THE T-CELL-ANTIGEN RECEPTOR-MEDIATED SIGNAL-TRANSDUCTION PATHWAY", Journal of leukocyte biology, 55(2), 1994, pp. 265-271

Abstract

T cell-mediated immune responses are initiated by interaction of antigen bound to a glycoprotein encoded by the major histocompatibility complex with the T cell antigen receptor (TCR). These recognition and binding steps are followed by multiple intracellular biochemical events. The earliest event detected is an increase in intracellular protein tyrosine phosphorylation that involves a complex interaction of tyrosine kinases and phosphatases. Subsequently, one observes an increase in protein serine/threonine phosphorylation, phospholipid hydrolysis, andchanges in intracellular Ca2+ levels. These and other biochemical changes lead to cell proliferation, differentiation, and acquisition of effector functions. While binding of extracellular growth factors to receptors containing cytoplasmic protein tyrosine kinase (PTK) domains induces direct activation of their kinase activity, the multichain TCR lacks an intrinsic kinase domain and therefore represents a distinct type of receptor. It transduces signals via the interaction with, and activation of, nbn-receptor PTKs. Recent efforts directed at defining the TCR-linked signaling pathways have provided insight into the regulatory role of three PTKs, and the functional importance of some unique protein motifs in both TCR subunits and PTKs, which mediate critical protein-protein interactions in this pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:26:09