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Titolo:
PRODUCTION OF NO-CARRIER-ADDED (CU)-C-64 FROM ZINC METAL IRRADIATED UNDER BORON SHIELDING
Autore:
ZINN KR; CHAUDHURI TR; CHENG TP; MORRIS JS; MEYER WA;
Indirizzi:
UNIV MISSOURI,RES REACTOR COLUMBIA MO 65211
Titolo Testata:
Cancer
fascicolo: 3, volume: 73, anno: 1994, supplemento:, S
pagine: 774 - 778
SICI:
0008-543X(1994)73:3<774:PON(FZ>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTRON-ACTIVATION ANALYSIS;
Keywords:
(CU)-C-64; COPPER-64; RADIONUCLIDE; RADIOISOTOPE; RADIOIMMUNODIAGNOSIS; POSITRON EMISSION TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
K.R. Zinn et al., "PRODUCTION OF NO-CARRIER-ADDED (CU)-C-64 FROM ZINC METAL IRRADIATED UNDER BORON SHIELDING", Cancer, 73(3), 1994, pp. 774-778

Abstract

Background. Positron emission tomography offers advantages for radioimmunodiagnosis of cancer but requires radionuclides of appropriate half-life that have high specific activity and high radio-purity. This work was designed to develop a viable method to produce and purify Cu-64, which has high specific activity, for positron emission tomography. Methods. Cu-64 was produced at the University of Missouri Research Reactor by the nuclear reaction, Zn-64(n,p)Cu-64. Highly pure zinc metal (99.9999%) was irradiated in a specially designed boron nitride lined container, which minimized thermal neutron reactions during irradiation. A new two-step procedure was developed to chemically separate the no-carrier-added Cu-64 from the zinc metal target. Results. Cu-64 recovery for 24 runs averaged 0.393 (+/-0.007) mCi per milligram of zinc irradiated. The boron-lined irradiation container reduced unwanted zinc radionuclides 14.3-fold. Zinc radionuclides and non-radioactive zinc were separated successfully from the Cu-64. The new separation technique was fast (2 hours total time) and highly efficient for removing the zinc. The zinc separation factor for this technique averaged 8.5 X 10(-8), indicating less than 0.0000085% of the zinc remained after separation. Thus far, the highest Cu-64 specific activity at end of irradiation was 683 Ci/mg Cu, with an average of 512 Ci/mg Cu for the last sixanalyzed runs. Conclusion. The boron-lined irradiation container has sufficient capacity for 75-fold larger-sized zinc targets (up to 45 g). The new separation technique was excellent for separating Cu-64, which appears to be a radionuclide with great potential for positron emission tomography.

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Documento generato il 10/08/20 alle ore 07:51:59