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Titolo:
ROLE OF NITRIC-OXIDE IN MODULATING THE LONG-TERM RENAL AND HYPERTENSIVE ACTIONS OF NOREPINEPHRINE
Autore:
GRANGER J; SCHNACKENBERG C; NOVAK J; TUCKER B; MILLER T; MORGAN S; KASSAB S;
Indirizzi:
UNIV MISSISSIPPI,MED CTR,DEPT PHYSIOL & BIOPHYS,2500 N STATE ST JACKSON MS 39216
Titolo Testata:
Hypertension
fascicolo: 1, volume: 29, anno: 1997,
parte:, 2
pagine: 205 - 209
SICI:
0194-911X(1997)29:1<205:RONIMT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-II; CONSCIOUS DOGS; VASOCONSTRICTION;
Keywords:
ENDOTHELIAL FACTORS; KIDNEY; RENAL; HEMODYNAMICS; ARTERIAL PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J. Granger et al., "ROLE OF NITRIC-OXIDE IN MODULATING THE LONG-TERM RENAL AND HYPERTENSIVE ACTIONS OF NOREPINEPHRINE", Hypertension, 29(1), 1997, pp. 205-209

Abstract

We have previously reported that nitric oxide (NO) plays an importantrole in protecting the renal vasculature from acute norepinephrine-induced vasoconstriction. The purpose of this study was to determine theimportance of this interaction between NO and norepinephrine in long-term control of renal hemodynamics and arterial pressure. To achieve this goal, we examined the effects of an intrarenal infusion of norepinephrine (NE) (0.1 mu g . kg(-1). min(-1)) for 7 days in conscious, chronically instrumented control dogs and in dogs pretreated with a synthesis inhibitor, L-NAME (3 mu g . kg(-1). min(-1) intrarenally). Both groups of dogs also received captopril (15 mu g . kg(-1). min(-1)) plusangiotensin II intravenously to clamp the renin-angiotensin system throughout the protocol. In control dogs (n = 6), intrarenal infusion ofNE decreased renal plasma flow by 9% (134 +/- 10 to 122 +/- 14 mL/min) and glomerular filtration rate by 16% (49 +/- 4 to 41 +/- 5 ml/min) while having no effect on mean arterial pressure (100 +/- 3 to 98 +/- 4 mm Hg). In marked contrast, in dogs pre treated with intrarenal L-NAME (n = 9), NE decreased renal plasma flow by 37% (129 +/- 8 to 81 +/-16 ml/min) and glomerular filtration rate by 32% (47 +/- 3 to 32 +/- 5 ml/min) while increasing mean arterial pressure from 104 +/- 5 to 113 +/- 6 mm Hg. The results of this study demonstrate that NO plays an important role in modulating the long-term actions of NE on renal function and arterial pressure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 03:31:57