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Titolo:
BASIC FIBROBLAST GROWTH FACTOR-INDUCED INCREASE IN I-125 HUMAN CHORIONIC-GONADOTROPIN BINDING TO LUTEINIZING-HORMONE RECEPTORS IN CULTURED IMMATURE LEYDIG-CELLS IS MEDIATED BY BINDING TO HEPARAN-SULFATE PROTEOGLYCANS
Autore:
MURONO EP; WASHBURN AL; GOFORTH DP; WU NX;
Indirizzi:
DORN VET ADM HOSP,RES SERV,ADM BLDG 28 COLUMBIA SC 29208 UNIV S CAROLINA,SCH MED,DEPT MED COLUMBIA SC 29208 UNIV S CAROLINA,SCH MED,DEPT PHYSIOL COLUMBIA SC 29208
Titolo Testata:
Molecular and cellular endocrinology
fascicolo: 1-2, volume: 97, anno: 1993,
pagine: 109 - 114
SICI:
0303-7207(1993)97:1-2<109:BFGFII>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBENDOTHELIAL EXTRACELLULAR-MATRIX; PLASMINOGEN-ACTIVATOR PRODUCTION; CAPILLARY ENDOTHELIAL-CELLS; 5-ALPHA-REDUCTASE ACTIVITY; BASEMENT-MEMBRANE; STIMULATION; STEROIDOGENESIS; MOLECULES; SECRETION; TISSUES;
Keywords:
LEYDIG CELL; FIBROBLAST GROWTH FACTOR; I-125 HCG BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
E.P. Murono et al., "BASIC FIBROBLAST GROWTH FACTOR-INDUCED INCREASE IN I-125 HUMAN CHORIONIC-GONADOTROPIN BINDING TO LUTEINIZING-HORMONE RECEPTORS IN CULTURED IMMATURE LEYDIG-CELLS IS MEDIATED BY BINDING TO HEPARAN-SULFATE PROTEOGLYCANS", Molecular and cellular endocrinology, 97(1-2), 1993, pp. 109-114

Abstract

Previous studies have shown that basic fibroblast growth (bFGF) has abiphasic effect on I-125-hCG binding to LH receptors in cultured Leydig cells from immature rats. Low concentrations of bFGF (0.1-1.0 ng/ml) progressively decreased binding, while higher concentrations (10-100ng/ml) progressively increased binding above nadir levels. In the present studies, treatment of cultured immature Leydig cells with heparinase I and/or heparinase III, which enzymatically remove heparan sulfate proteoglycans, had no effect on basal binding of I-125-hCG to LH receptors or the decrease in binding due to treatment with low bFGF concentrations; however, this treatment dramatically reduced the secondary increase in binding following the addition of higher bFGF concentrations. These results strongly support the idea that the secondary increase in I-125-hCG binding to LH receptors elicited by treatment with higher bFGF concentrations is mediated by bFGF binding to heparan sulfate proteoglycans associated with the plasma membrane and/or extracellularmatrix.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:27:13