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Titolo:
IMPAIRED LEFT-VENTRICULAR FILLING RATE INDUCED BY TREATMENT WITH RECOMBINANT INTERLEUKIN-2 FOR ADVANCED CANCER
Autore:
FRAGASSO G; TRESOLDI M; BENTI R; VIDAL M; MARCATTI M; BORRI A; BESANA C; GERUNDINI PP; RUGARLI C; CHIERCHIA S;
Indirizzi:
IST SCI H SAN RAFFAELE,DIV CARDIOL,VIA OLGETTINA 60 I-20132 MILAN ITALY UNIV MILAN,IST SCI H SAN RAFFAELE,DIV INTERNAL MED 2 MILAN ITALY IST SCI H SAN RAFFAELE,DEPT NUCL MED MILAN ITALY
Titolo Testata:
British Heart Journal
fascicolo: 2, volume: 71, anno: 1994,
pagine: 166 - 169
SICI:
0007-0769(1994)71:2<166:ILFRIB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HIGH-DOSE INTERLEUKIN-2; ACTIVATED KILLER CELLS; NITRIC-OXIDE SYNTHESIS; SEPTIC SHOCK; CYTOKINE INHIBITION; CARDIAC MYOCYTES; CYCLIC-AMP; ENDOTOXIN; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
G. Fragasso et al., "IMPAIRED LEFT-VENTRICULAR FILLING RATE INDUCED BY TREATMENT WITH RECOMBINANT INTERLEUKIN-2 FOR ADVANCED CANCER", British Heart Journal, 71(2), 1994, pp. 166-169

Abstract

Background-Immunotherapy with recombinant interleukin 2 (rIL 2) has been extensively used to treat cancer but its use has been hampered by serious side effects including severe hypotension, arrhythmias, and myocardial infarction. Objective-To assess the effects of rIL 2 on humanleft ventricular function. Methods-Left ventricular (LV) function wasmonitored in 22 patients (9 women, 13 men) (mean (SD) age 53 (10) years) undergoing a 120 h continuous intravenous infusion of rIL 2 (18 x 10(6) IU/m(2)/day) for melanoma (4), renal cell (16), ovarian (1), andcolon cancer (1). Radionuclide ventriculography was performed before and 1 h after the end of treatment. Ejection fraction (EF), peak emptying rate (PER), peak filling rate (PFR), and regional left ventricularwall motion were analysed. Heart rate (HR), central venous pressure (CVP), systolic and diastolic blood pressures the electrocardiogram. and myocardial enzyme concentrations were monitored throughout the study. Results-All variables (mean (SD)) were normal before rIL 2 was given. After rIL 2 administration HR increased significantly from 84 (11) to 125 (18) beats/min (p < 0.0001), SBP fell from 128 (11) to 100 (9) mm Hg (p < 0.001) and DBP from 76 (9) to 65 (7) mm Hg (p < 0.0001). CVPdecreased from 3.70 (3.2) to 1.30 (0.45) cm H2O (p < 0.001). EF (65 (7) to 64 (8%) and PER (3.56 (0.60) to 3.86 (0.83) EDV/s) did not change significantly. PFR decreased significantly at the end of the rIL 2 infusion from 2.68 (0.46) to 2.37 (0.43) EDV/s (p < 0.01). Left ventricular segmental hypokinesia developed in 6 patients. Myocardial enzyme concentrations remained normal throughout the study. Conclusions-The results of this study confirmed that rIL 2 produces important haemodynamic changes, predominantly related to decreased systemic resistance. However, the observed reduction in PFR in most patients suggested that rIL 2 might exert its action at the level of the heart muscle itself. The localised systolic dysfunction in some patients suggested that rIL2 might also adversely affect myocardial perfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 09:05:16