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Titolo:
HUMAN HEPATOCYTE POLYPLOIDIZATION KINETICS IN THE COURSE OF LIFE-CYCLE
Autore:
KUDRYAVTSEV BN; KUDRYAVTSEVA MV; SAKUTA GA; STEIN GI;
Indirizzi:
RUSSIAN ACAD SCI,INST CYTOL ST PETERSBURG 194064 RUSSIA
Titolo Testata:
Virchows Archiv including cell pathology including molecular pathology
fascicolo: 6, volume: 64, anno: 1993,
pagine: 387 - 393
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER CELLS;
Keywords:
CYTOPHOTOMETRY; LIVER CELLS; POSTNATAL GROWTH; AGING; CELL TRANSITION RATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
B.N. Kudryavtsev et al., "HUMAN HEPATOCYTE POLYPLOIDIZATION KINETICS IN THE COURSE OF LIFE-CYCLE", Virchows Archiv including cell pathology including molecular pathology, 64(6), 1993, pp. 387-393

Abstract

The processes of polyploidization in normal human liver parenchyma from 155 individuals aged between 1 day and 92 years were investigated by Feulgen-DNA cytophotometry. It was shown that polyploid hepatocytes appear in individuals from 1 to 5 years old. Up to the age of 50 yearsthe accumulation rate of binucleate and polyploid cells is very slow,but subsequently hepatocyte polyploidization is intensified, and in patients aged 86-92 years the relative number of cells with polyploid nuclei is about 27%. Only a few hepatocytes in the normal human liver reach 16C and 8C x 2 ploidy levels for mononucleate and binucleate cells respectively. Using a mathematical modeling method, it was shown that during postnatal liver growth the polyploidization process in human liver is similar to that in the rat, and that polyploid cells are formed mainly from binucleate cells. As in rats, prior to an increase in ploidy level, diploid human hepatocytes can pass several times through the usual mitotic cycles maintaining their initial ploidy level. Afterbirth, only one in ten hepatocytes starting DNA synthesis enters the polyploidization process. At maturity about 60% of 2C-hepatocytes starting DNA synthesis divide by conventional mitosis, the rest dividing by acytokinetic mitosis leading to the formation of binucleate cells. During ageing the probability of hepatocyte polyploidization increases and in this period there are two polyploid or binucleate cells for every diploid dividing by conventional mitosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 04:33:02