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Titolo: A HYDROPHILIC TETRAHYDRO-BETA-CARBOLINE IN HUMAN URINE
Autore: HORIUCHI K; YONEKAWA O; IWAHARA K; KANNO T; KURIHARA T; FUJISE Y;
- Indirizzi:
- HAMAMATSU UNIV,SCH MED,DEPT CHEM HAMAMATSU SHIZUOKA 43131 JAPAN HAMAMATSU UNIV,SCH MED,DEPT LAB MED HAMAMATSU SHIZUOKA 43131 JAPAN SAPPORO BREWERIES LTD,PHARMACEUT RES LABS SHIZUOKA 425 JAPAN
- Titolo Testata:
- Journal of Biochemistry
fascicolo: 2,
volume: 115,
anno: 1994,
pagine: 362 - 366
- SICI:
- 0021-924X(1994)115:2<362:AHTIHU>2.0.ZU;2-L
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- PSYCHOACTIVE COMPOUNDS; MAMMALIAN BODY; N-METHYLATION; BRAIN; RAT; IDENTIFICATION; ACID;
- Keywords:
- BETA-CARBOLINE; GABA-RECEPTOR; HUMAN URINE; TETRAHYDRO-BETA-CARBOLINE; WATER SOLUBLE;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 27
- Recensione:
- Indirizzi per estratti:
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- Citazione:
- K. Horiuchi et al., "A HYDROPHILIC TETRAHYDRO-BETA-CARBOLINE IN HUMAN URINE", Journal of Biochemistry, 115(2), 1994, pp. 362-366
Abstract
A substance that exhibited a tryptophan-like fluorescence peak at 354nm on excitation at 295 nm at neutral pH was isolated from human urine. This compound was determined by visible-light absorption spectroscopy, fluorescence spectroscopy, H-1 and C-13 NMR spectroscopies, and FAB-MS to be 1-(1',2',3',4',5' entyl)-1,2,3,4-tetrahydro-2-carboline-3-carboxylic acid. This compound, named tetrahydropentoxyline, is a new type of hydrophilic tetrahydro-beta-carboline, and its elution positionwas between those of 4-pyridoxic acid and kynurenic acid on C-18 reversed-phase HPLC. The amount of tetrahydropentoxyline excreted in the urine of normal subjects [n=21; age, 45 (SD 20) years] was about 5.2 (SD 1.0) mg per day.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:42:57