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Titolo:
CAUSES OF KIDNEY ALLOGRAFT LOSS IN A LARGE PEDIATRIC POPULATION AT A SINGLE-CENTER
Autore:
CHAVERS BM; KIM EM; MATAS AJ; GILLINGHAM KJ; NAJARIAN JS; MAUER SM;
Indirizzi:
UNIV MINNESOTA,DEPT PEDIAT,13-240 MOOS TOWER,BOX 491 UMHC,515 DELWAREST SE MINNEAPOLIS MN 55455
Titolo Testata:
Pediatric nephrology
fascicolo: 1, volume: 8, anno: 1994,
pagine: 57 - 61
SICI:
0931-041X(1994)8:1<57:COKALI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Keywords:
ALLOGRAFT LOSS; CAUSES; LARGE SINGLE-CENTER PEDIATRIC POPULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
B.M. Chavers et al., "CAUSES OF KIDNEY ALLOGRAFT LOSS IN A LARGE PEDIATRIC POPULATION AT A SINGLE-CENTER", Pediatric nephrology, 8(1), 1994, pp. 57-61

Abstract

At our institution, 521 kidney transplants were performed in 429 children (mean age 8.7 +/- 5.6-years) between 1969 and 1991. Of these transplants, 408 were primary, 113 were retransplants, 347 were living related, 171 were cadaver, and 3 were living nonrelated. Immunosuppression consisted of prednisone, azathioprine, and Minnesota antilymphocyte globulin (non-CSA) in 339 patients, total lymphoid irradiation in 8, and, more recently, cyclesporine (CSA) in addition in 168 patients. Average followup was 8.8 +/- 6.0 years. Actuarial graft survival in the non-CSA versus CSA groups at 1 year was 77.0% versus 85.7%; at 5- years, 59.6% versus 71.9%. Of 136 non-CSA patients, causes of graft loss at5 years included: chronic rejection in 55 (40.4%), acute rejection in27 (19.9%), recurrent disease in 16 (11.8%), technical complications in 8 (5.9%), infectious complications in 4 (2.9%), other causes in 5 (3.7%), and death with a functioning graft in 21 (15.4%). Of 40 CSA patients, causes of graft loss at 5 years included: chronic rejection in 16 (40.0%), acute rejection in 8 (20.0%), recurrent disease in 6 (15.0%), technical complications in 3 (7.5%), other causes in 2 (5.0%), anddeath with a functioning graft in 5 (12.5%). The causes of graft lossdid not significantly differ in the non-CSA and CSA groups. Chronic rejection was the most common cause of graft loss in both groups. Research focusing on chronic rejection is needed to improve graft outcome in pediatric kidney transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:38:59