Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ALPHA(1)-ADRENOCEPTORS IN THE CONDUCTION SYSTEM OF RAT HEARTS
Autore:
SAITO K; SUETSUGU T; OKU Y; KURODA A; TANAKA H;
Indirizzi:
NATL INST FITNESS & SPORTS,CTR HLTH SERV,1 SHIROMIZU KANOYA KAGOSHIMA89123 JAPAN KAGOSHIMA UNIV,FAC MED,DEPT INTERNAL MED 1 KAGOSHIMA 890 JAPAN
Titolo Testata:
British Journal of Pharmacology
fascicolo: 2, volume: 111, anno: 1994,
pagine: 465 - 468
SICI:
0007-1188(1994)111:2<465:AITCSO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE RECEPTOR AUTORADIOGRAPHY; BETA-2-ADRENOCEPTOR SUBTYPES; PURKINJE-FIBERS; NODE; ALPHA-1-ADRENOCEPTORS; BETA-1-ADRENOCEPTOR; CATECHOLAMINES; STIMULATION;
Keywords:
ALPHA(1)-ADRENOCEPTORS; SINOATRIAL NODE; ATRIOVENTRICULAR NODE; AUTORADIOGRAPHY; RAT HEART;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
K. Saito et al., "ALPHA(1)-ADRENOCEPTORS IN THE CONDUCTION SYSTEM OF RAT HEARTS", British Journal of Pharmacology, 111(2), 1994, pp. 465-468

Abstract

1 We have characterized alpha(1)-adrenoceptor in the conduction systems of the rat heart by quantitative autoradiography. 2 Consecutive 20 mu m thick sections from a single rat heart containing the sinoatrial (SA) node and atrioventricular (AV) node were incubated with increasing concentrations of [H-3]-prazosin with or without 10 mu M phentolamine. After exposure to H-3-Ultrofilm, optical densities corresponding tothe SA node and AV node were determined by computerized densitometry after comparison with H-3 standards. 3 The SA node and AV node were stained heavily for cholinesterase and they contained a higher concentration of alpha(1)-adrenoceptors than the adjacent myocardium without a significant change in the affinity. 4 These results support the hypothesis that alpha(1)-adrenoceptors may play an important role not only in inotropism but also in chronotropism of rat hearts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 01:23:22