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Titolo:
DECREASED BONE-MINERAL DENSITY IN CHILDREN WITH PHENYLKETONURIA
Autore:
ALLEN JR; HUMPHRIES IRJ; WATERS DL; ROBERTS DCK; LIPSON AH; HOWMANGILES RG; GASKIN KJ;
Indirizzi:
CHILDRENS HOSP,JAMES FAIRFAX INST PAEDIAT CLIN NUTR,CTR CHILDRENS ASSESSMENT,POB 34 CAMPERDOWN NSW 2050 AUSTRALIA CHILDRENS HOSP,JAMES FAIRFAX INST PAEDIAT CLIN NUTR,CTR CHILDRENS ASSESSMENT CAMPERDOWN NSW 2050 AUSTRALIA CHILDRENS HOSP,DEPT NUCL MED CAMPERDOWN NSW AUSTRALIA UNIV NEWCASTLE,FAC HLTH SCI,DEPT NUTR & DIETET NEWCASTLE NSW AUSTRALIA
Titolo Testata:
The American journal of clinical nutrition
fascicolo: 2, volume: 59, anno: 1994,
pagine: 419 - 422
SICI:
0002-9165(1994)59:2<419:DBDICW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM INTAKE; MASS;
Keywords:
BONE DENSITY; CHILDREN; PHENYLKETONURIA; CALCIUM (DIETARY); PHOSPHORUS (DIETARY); MAGNESIUM (DIETARY);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Allen et al., "DECREASED BONE-MINERAL DENSITY IN CHILDREN WITH PHENYLKETONURIA", The American journal of clinical nutrition, 59(2), 1994, pp. 419-422

Abstract

Previous studies have suggested that children with phenylketonuria (PKU) have a reduction in bone mineralization compared with control subjects. To investigate this, bone mineral density (BMD) of the total body (TBMD) was measured in 32 prepubertal children with PKU and in 95 age-matched control subjects. Spine bone mineral density (SBMD) was alsorecorded in a subset, 24 with PKU and 55 control subjects. The effectof dietary intake on bone mass was assessed in 30 of the children with PKU and in 12 control subjects. In the children with PKU, TBMD and SBMD were significantly lower than in the control subjects after adjustment for height and weight (P = 0.03 and P = 0.003, respectively). Thechildren with PKU had a higher intake of calcium (P < 0.0001), phosphorus (P = 0.0002), and magnesium (P < 0.0001), suggesting that their lower BMD occurred despite an adequate diet based on current recommendations. Further study is needed to establish the cause of this deficit in bone mass and the benefit of additional nutritional support to reverse this problem.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:03:38