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Titolo:
PREFERENTIAL ACTIVATION OF DOPAMINE OVERFLOW IN PREFRONTAL CORTEX PRODUCED BY CHRONIC CLOZAPINE TREATMENT
Autore:
YOUNGREN KD; MOGHADDAM B; BUNNEY BS; ROTH RH;
Indirizzi:
YALE UNIV,SCH MED,DEPT PHARMACOL,333 CEDAR ST NEW HAVEN CT 06510 YALE UNIV,SCH MED,DEPT PHARMACOL NEW HAVEN CT 06510 YALE UNIV,SCH MED,DEPT PSYCHIAT NEW HAVEN CT 06510 YALE UNIV,SCH MED,INTERDEPT NEUROSCI PROGRAM NEW HAVEN CT 06510 W HAVEN VA MED CTR W HAVEN CT 06516
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 165, anno: 1994,
pagine: 41 - 44
SICI:
0304-3940(1994)165:1-2<41:PAODOI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS; PHARMACOLOGICAL RESPONSIVENESS; INVIVO MICRODIALYSIS; BASAL DOPAMINE; HALOPERIDOL; STRIATUM; RELEASE; RAT; SCHIZOPHRENIA; METABOLISM;
Keywords:
CLOZAPINE; DOPAMINE; MICRODIALYSIS; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; STRIATUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
K.D. Youngren et al., "PREFERENTIAL ACTIVATION OF DOPAMINE OVERFLOW IN PREFRONTAL CORTEX PRODUCED BY CHRONIC CLOZAPINE TREATMENT", Neuroscience letters, 165(1-2), 1994, pp. 41-44

Abstract

The effect of chronic treatment with clozapine on extracellular dopamine levels in the rat striatum, nucleus accumbens and medial prefrontal cortex (mPFC) was examined using intracerebral microdialysis. Clozapine (20 mg/kg/day x 21 days in drinking water) increased basal dopamine release in the mPFC but had no effect in the striatum or nucleus accumbens. After chronic treatment, an acute dose of clozapine (20 mg/kg i.p.) produced large and long-lasting increases in extracellular dopamine in all three brain regions. The data suggest that chronic clozapine produces a sustained enhancement in dopaminergic tone in the mPFC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:40:20