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Titolo:
MEMANTINE SELECTIVELY DEPRESSES NMDA RECEPTOR-MEDIATED RESPONSES OF RAT SPINAL NEURONS IN-VIVO
Autore:
HERRERO JF; HEADLEY PM; PARSONS CG;
Indirizzi:
UNIV BRISTOL,SCH MED SCI,DEPT PHYSIOL,UNIV WALK BRISTOL BS8 1TD ENGLAND UNIV BRISTOL,SCH MED SCI,DEPT PHYSIOL BRISTOL BS8 1TD ENGLAND MERZ & CO GMBH W-6000 FRANKFURT 1 GERMANY
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 165, anno: 1994,
pagine: 37 - 40
SICI:
0304-3940(1994)165:1-2<37:MSDNRR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASPARTATE; CHANNEL;
Keywords:
MEMANTINE; KETAMINE; EXCITATORY AMINO ACID; NMDA; SPINAL CORD; NOCICEPTION; IONTOPHORESIS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Herrero et al., "MEMANTINE SELECTIVELY DEPRESSES NMDA RECEPTOR-MEDIATED RESPONSES OF RAT SPINAL NEURONS IN-VIVO", Neuroscience letters, 165(1-2), 1994, pp. 37-40

Abstract

The clinically used agent memantine (1-amino-3,5-dimethyladamantane) can act as an antagonist of NMDA (N-methyl-D-aspartate) when tested invitro, but whether this applies with clinically relevant doses under in vivo conditions is not clear. In this study memantine has been compared with the known NMDA channel blocker ketamine, by intravenous administration in anaesthetized rats, for effects on the responses of spinal neurones both to iontophoretic administrations of excitatory amino acids and to peripheral noxious stimuli. Spontaneous activity, nociceptive responses and blood pressure were not significantly affected by memantine and ketamine, whereas both agents selectively reduced responses to NMDA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:07:04