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Titolo:
SCREENING FOR SPECIFIC INHIBITORS OF PHAGOCYTOSIS OF THIOGLYCOLATE-ELICITED MACROPHAGES
Autore:
MAGAE J; NAGI T; TAKAKU K; KATAOKA T; KOSHINO H; URAMOTO M; NAGAI K;
Indirizzi:
TOKYO INST TECHNOL,DEPT BIOENGN,MIDORI KU,4259 NAGATSUTA CHO YOKOHAMAKANAGAWA 227 JAPAN RIKEN WAKO SAITAMA 35101 JAPAN TAMAGAWA UNIV,FAC AGR MACHIDA TOKYO 194 JAPAN
Titolo Testata:
Bioscience, biotechnology, and biochemistry
fascicolo: 1, volume: 58, anno: 1994,
pagine: 104 - 107
SICI:
0916-8451(1994)58:1<104:SFSIOP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GTP-BINDING PROTEIN; POTENT INHIBITOR; PHOSPHATASE INHIBITOR; ANTIBIOTIC CERULENIN; HUMAN-NEUTROPHILS; TAUTOMYCIN; CELLS; STAUROSPORINE; MEMBRANE; KINASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
J. Magae et al., "SCREENING FOR SPECIFIC INHIBITORS OF PHAGOCYTOSIS OF THIOGLYCOLATE-ELICITED MACROPHAGES", Bioscience, biotechnology, and biochemistry, 58(1), 1994, pp. 104-107

Abstract

Phagocytosis is one of the basic and characteristic properties of macrophages. We screened metabolites of Actinomyces for low molecular weight substances that selectively inhibited phagocytosis of dried yeast but not pinocytosis of neutral red by thioglycollate-elicited peritoneal macrophages. Inhibitors of actin filament organization, protein kinases, respiration, and lipid synthesis selectively inhibited phagocytosis, and blockers of proton gradients selectively inhibited pinocytosis. This suggests that these functions are differently regulated. We applied this system to screening of metabolites of Actinomyces, and identified mycotrienin, piericidin, and genistein as selective inhibitors of phagocytosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:59:26