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Titolo:
ACUTE AND CHRONIC TREATMENT WITH 5-HT REUPTAKE INHIBITORS - DIFFERENTIALLY MODULATE EMOTIONAL RESPONSES IN ANXIETY MODELS IN RODENTS
Autore:
GRIEBEL G; MOREAU JL; JENCK F; MISSLIN R; MARTIN JR;
Indirizzi:
LAB PSYCHOBIOL,7 RUE UNIV F-67000 STRASBOURG FRANCE F HOFFMANN LA ROCHE & CO LTD,PRECLIN RES,DIV PHARMA CH-4002 BASEL SWITZERLAND
Titolo Testata:
Psychopharmacology
fascicolo: 3-4, volume: 113, anno: 1994,
pagine: 463 - 470
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; FRONTAL-CORTEX; ANIMAL-MODELS; SEROTONIN; BEHAVIOR; RAT; 5-HYDROXYTRYPTAMINE; FLUOXETINE; INVIVO; DRUGS;
Keywords:
CIANOPRAMINE; CITALOPRAM; 5-HT REUPTAKE INHIBITORS; LIGHT/DARK CHOICE PROCEDURE; ELEVATED PLUS-MAZE TEST; ANXIETY; NEOPHOBIA; ACUTE AND CHRONIC TREATMENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
G. Griebel et al., "ACUTE AND CHRONIC TREATMENT WITH 5-HT REUPTAKE INHIBITORS - DIFFERENTIALLY MODULATE EMOTIONAL RESPONSES IN ANXIETY MODELS IN RODENTS", Psychopharmacology, 113(3-4), 1994, pp. 463-470

Abstract

This study investigated behavioural effects of very potent 5-HT reuptake inhibitors after acute treatment (cianopramine and citalopram), aswell as after chronic treatment (cianopramine), in two behavioural models of anxiety: 1) the light/dark choice procedure in mice and 2) theelevated plus-maze test in rats. In addition, the responses of mice to novelty in a free exploration paradigm were assessed after acute administration of both drugs. A single injection of cianopramine or citalopram increased neophobic reactions in the free exploration test. Furthermore, these drugs increased the avoidance reaction to a brightly illuminated chamber in the light/dark choice procedure as well as to open arms in the elevated plus-maze test. In contrast, after chronic treatment (10 mg/kg IP, once daily for 21 days) of cianopramine, anxiogenic-like effects were no longer produced in the light/dark choice paradigm whereas in the elevated plus-maze test, anxiolytic-like effects appeared. These results shed more light on the 5-HT hypothesis of anxiety, insofar as the increased availability of 5-HT resulting here from reuptake inhibition seems to initially result in an increased emotional reactivity which, however, subsequently disappears during chronic treatment.

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Documento generato il 22/01/20 alle ore 12:55:00