Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
AN EXAMINATION OF THE BEHAVIORAL SPECIFICITY OF HYPOPHAGIA INDUCED BY5-HT1B, 5-HT1C AND 5-HT2 RECEPTOR AGONISTS USING THE POSTPRANDIAL SATIETY SEQUENCE IN RATS
Autore:
KITCHENER SJ; DOURISH CT;
Indirizzi:
WYETH RES UK LTD,DEPT NEUROPHARMACOL,HUNTERCOMBE LANE S MAIDENHEAD BERKS SL6 OPH ENGLAND MERCK SHARP & DOHME LTD,RES LABS,NEUROSCI RES CTR HARLOW CM20 2QR ESSEX ENGLAND
Titolo Testata:
Psychopharmacology
fascicolo: 3-4, volume: 113, anno: 1994,
pagine: 369 - 377
Fonte:
ISI
Lingua:
ENG
Soggetto:
1-(2,5-DIMETHOXY-4-IODOPHENYL)-2-AMINOPROPANE DOI; TETRALIN 8-OH-DPAT; BINDING-SITES; RU-24969; BRAIN; 5-HYDROXYTRYPTAMINE; ANOREXIA; TFMPP; FENFLURAMINE; FLUOXETINE;
Keywords:
5-HT1B; 5-HT1C; 5-HT2 RECEPTORS; FEEDING; SATIETY SEQUENCE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Kitchener e C.T. Dourish, "AN EXAMINATION OF THE BEHAVIORAL SPECIFICITY OF HYPOPHAGIA INDUCED BY5-HT1B, 5-HT1C AND 5-HT2 RECEPTOR AGONISTS USING THE POSTPRANDIAL SATIETY SEQUENCE IN RATS", Psychopharmacology, 113(3-4), 1994, pp. 369-377

Abstract

Previous studies have shown that administration of 5-HT1B, 5-HT1C or 5-HT2 agonists decreases food intake in rats. However, it has not beenestablished whether these drugs induce satiety or decrease feeding bya non-specific mechanism. In the present study the postprandial satiety sequence was used to characterise the actions of the 5-HT2 receptoragonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), the 5-HT1B/5-HT1C receptor agonists, 1-(3-chorophenyl) piperazine (mCPP) and 1-[3-(trifluoromethyl)phenyl] piperazine (TFMPP), and the 5-HT1B agonist, ethoxy-3-(1,2,3,6-tetrahydlro-4-pyridinyl)H-indole (RU 24969), on feeding in rats. All four compounds reduced food intake in rats that had been food deprived overnight. The 5-HT1B/5-HT1C agonists, TFMPP (ata dose of 1.0 mg/kg) and mCPP (at a dose of 3.0 mg/kg), appeared to produce satiety as their effects on the satiety sequence were similar to those induced by a food pre-load. In contrast, the 5-HT1B agonist RU24969 and the 5-HT2 agonist DOI did not produce behavioural profiles that resembled satiety. Thus, RU 24969 elevated active behaviours and did not accelerate resting whereas DOI appeared to induce hypophagia by a non-specific fragmentation of behaviour. The results suggest that simultaneous activation of 5-HT1B and 5-HT1C receptors may be sufficient to elicit behaviourally specific satiety in the rat. In contrast, selective activation of 5-HT2 receptors does not induce satiety but elicits active behaviours and decreases feeding by response competition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:10:38