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Titolo:
AN ACUTE EFFECT OF TRIAZOLAM ON MUSCARINIC CHOLINERGIC RECEPTOR-BINDING IN THE HUMAN BRAIN MEASURED BY POSITRON EMISSION TOMOGRAPHY
Autore:
SUHARA T; INOUE O; KOBAYASHI K; SATOH T; TATENO Y;
Indirizzi:
NATL INST RADIOL SCI,DIV CLIN RES,INAGE KU,9-1 ANAGAWA 4-CHOME CHIBA 263 JAPAN
Titolo Testata:
Psychopharmacology
fascicolo: 3-4, volume: 113, anno: 1994,
pagine: 311 - 317
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVING HUMAN-BRAIN; RAT-BRAIN; ENDOGENOUS DOPAMINE; N-METHYLSPIPERONE; H-3 RACLOPRIDE; BABOON BRAIN; HUMAN-MEMORY; MOUSE-BRAIN; INVIVO; BENZODIAZEPINES;
Keywords:
MUSCARINIC ACETYLCHOLINE RECEPTORS; BENZODIAZEPINE; NEURAL INTERACTIONS; PET; NMPB; HUMAN BRAIN; TRIAZOLAM; MEMORY; AMNESIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
T. Suhara et al., "AN ACUTE EFFECT OF TRIAZOLAM ON MUSCARINIC CHOLINERGIC RECEPTOR-BINDING IN THE HUMAN BRAIN MEASURED BY POSITRON EMISSION TOMOGRAPHY", Psychopharmacology, 113(3-4), 1994, pp. 311-317

Abstract

An acute effect of triazolam, a potent benzodiazepine agonist, on cholinergic receptor binding in the human brain was measured by PET (positron emission tomography) using [C-11]N-methyl-4-piperidylbenziIate ([C-11]NMPB), a potent muscarinic cholinergic receptor antagonist. Two PET scans were performed in each subject: (1) control scan; (2) after oral administration of 0.5 mg triazolam or placebo. The previously discussed amnestic effect of triazolam was measured by immediate and delayed recall of meaningful and meaningless syllables. A compartment modelemploying the radioactivity in the cerebellum as an input function was used for the quantification of receptor binding. The binding parameter, k(3), was decreased after triazolam administration in all measuredregions, whereas no change was observed after placebo treatment. The reduction compared to the control study varied from 8.6+/-3.7% in the temporal cortex to 16.3+/-6.3% in the thalamus. Triazolam administration impaired both immediate and delayed recall of syllables, whereas placebo administration had no effects. Benzodiazepine agonists are reported to decrease the cortical acetylcholine release. The decrease of acetylcholine release in the synaptic cleft might be the explanation forthe decreased binding of [C-11]NMPB.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:40:03