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Titolo:
CELLULAR METABOLIC HOMEOSTASIS DURING LARGE-SCALE CHANGE IN ATP TURNOVER RATES IN MUSCLES
Autore:
HOCHACHKA PW; MCCLELLAND GB;
Indirizzi:
UNIV BRITISH COLUMBIA,DEPT ZOOL,6270 UNIV BLVD VANCOUVER BC V6T 1Z4 CANADA
Titolo Testata:
Journal of Experimental Biology
fascicolo: 2, volume: 200, anno: 1997,
pagine: 381 - 386
SICI:
0022-0949(1997)200:2<381:CMHDLC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREATINE-KINASE; PHOSPHORYLCREATINE SHUTTLE; NARCINE-BRASILIENSIS; HUMMINGBIRD FLIGHT; WORK TRANSITIONS; SKELETAL-MUSCLE; RED MUSCLE; P-31 NMR; GLYCOLYSIS; RESPIRATION;
Keywords:
HOMEOSTASIS; MUSCLE; ATP TURNOVER; METABOLISM; REGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
P.W. Hochachka e G.B. Mcclelland, "CELLULAR METABOLIC HOMEOSTASIS DURING LARGE-SCALE CHANGE IN ATP TURNOVER RATES IN MUSCLES", Journal of Experimental Biology, 200(2), 1997, pp. 381-386

Abstract

The term homeostasis traditionally refers to the maintenance of a relatively constant internal milieu in the face of changing environmentalconditions or changing physiological function. Tissues such as skeletal and cardiac muscles must sustain very large-scale changes in ATP turnover rate during equally large changes in work. In many skeletal muscles, these changes can exceed 100-fold. In unique biological circumstances (for example, during periods of oxygen limitation, vasoconstriction and hypometabolism), tissues such as skeletal muscles may be obliged to sustain further decreases in ATP turnover rates and operate for varying periods at seriously suppressed ATP turnover rates. Examination of a number of cellular and whole-organism systems identifies ATP concentration as a key parameter of the interior milieu that is nearly universally 'homeostatic'; it is common to observe no change in ATP concentration even while the change in its turnover rate can increase or decrease by two orders of magnitude. A large number of other intermediates of cellular metabolism are also regulated within narrow concentration ranges, but none seemingly as precisely as is [ATP]. In fact, theonly other metabolite in aerobic energy metabolism that is seemingly as 'homeostatic' is oxygen - at least in working muscles, regulatory question is how such homeostasis intermediates in pathways of energy supply and energy demand is achieved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 23:20:15