Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PATTERN-FORMATION IN THE DEVELOPING SUPERIOR COLLICULUS - ONTOGENY OFTHE PERIODIC ARCHITECTURE IN THE INTERMEDIATE LAYERS
Autore:
ILLING RB; GRAYBIEL AM;
Indirizzi:
UNIV FREIBURG,HNO KLIN,DEPT OTORHINOLARYNGOL,MORPHOL BRAIN RES UNIT,KILLIANSTR 5 D-79106 FREIBURG GERMANY MASSACHUSETTS INST TECHNOL,DEPT BRAIN & COGNIT SCI CAMBRIDGE MA 00000
Titolo Testata:
Journal of comparative neurology
fascicolo: 3, volume: 340, anno: 1994,
pagine: 311 - 327
SICI:
0021-9967(1994)340:3<311:PITDSC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENKEPHALIN-LIKE IMMUNOREACTIVITY; OCULAR DOMINANCE COLUMNS; SACCADE-RELATED NEURONS; FETAL RHESUS-MONKEY; PRENATAL DEVELOPMENT; POSTNATAL-DEVELOPMENT; SUBSTANTIA-NIGRA; VISUAL-CORTEX; RETINOCOLLICULAR PROJECTIONS; CHOLINERGIC PROJECTIONS;
Keywords:
COLLICULAR PLATE; DEVELOPMENT; ACETYLCHOLINESTERASE; MODULAR ORGANIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
86
Recensione:
Indirizzi per estratti:
Citazione:
R.B. Illing e A.M. Graybiel, "PATTERN-FORMATION IN THE DEVELOPING SUPERIOR COLLICULUS - ONTOGENY OFTHE PERIODIC ARCHITECTURE IN THE INTERMEDIATE LAYERS", Journal of comparative neurology, 340(3), 1994, pp. 311-327

Abstract

The superior colliculus of mammals contains a striking neurochemical architecture in which histochemically identifiable compartments are distributed in an iterative arrangement in the intermediate layers. We used stains for acetylcholinesterase activity as a compartment marker to trace ontogenesis of this architecture during pre- and postnatal development in the domestic cat. We found that compartmentation in the intermediate collicular layers is virtually absent at birth, and only gradually emerges during the first weeks of postnatal life. Over the same postnatal period, acetylcholinesterase activity shifts from a predominantly perikaryal expression pattern immediately postnatally to a nearly exclusive localization in the neuropil at maturity. Remarkably, a striking compartmentation of the superior colliculus was readily apparent with acetylcholinesterase histochemistry prenatally. The first appearance of a periodic architecture in the superior colliculus was observed at embryonic day 34, a time at which the collicular plate had notyet become laminated. The compartments characterized by high levels of acetylcholinesterase activity then gained in prominence until late in the prenatal period, when they receded and disappeared. The loss of the acetylcholinesterase-positive compartments in the perinatal perioddid not reflect a loss of compartmentation altogether. Neonatally, there was a distinct compartmental architecture visible with enkephalin immunohistochemistry. The virtual absence of acetylcholinesterase-positive compartments in the superior colliculus at birth therefore reflects developmental regulation of enzyme expression in the compartments, not regulation of the compartments as structural entities. We concludethat the periodic architecture, which characterizes the intermediate collicular layers in the adult cat, arises early in ontogenesis. Theseobservations raise the possibility that the histochemical compartments are ontogenetic units that undergo remodelling as the superior colliculus matures. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:11:08