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Titolo:
ENKEPHALIN-POSITIVE AND ACETYLCHOLINESTERASE-POSITIVE PATCH SYSTEMS IN THE SUPERIOR COLLICULUS HAVE MATCHING DISTRIBUTIONS BUT DISTINCT DEVELOPMENTAL HISTORIES
Autore:
GRAYBIEL AM; ILLING RB;
Indirizzi:
UNIV FREIBURG,HNO KLIN,DEPT OTORHINOLARYNGOL,MORPHOL BRAIN RES UNIT,KILLIANSTR 5 D-79106 FREIBURG GERMANY UNIV FREIBURG,HNO KLIN,DEPT OTORHINOLARYNGOL,MORPHOL BRAIN RES UNIT D-79106 FREIBURG GERMANY MASSACHUSETTS INST TECHNOL,DEPT BRAIN & COGNIT SCI CAMBRIDGE MA 00000
Titolo Testata:
Journal of comparative neurology
fascicolo: 3, volume: 340, anno: 1994,
pagine: 297 - 310
SICI:
0021-9967(1994)340:3<297:EAAPSI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SACCADE-RELATED NEURONS; NIGRA PARS RETICULATA; SUBSTANTIA-NIGRA; EYE-MOVEMENTS; RETROGRADE TRANSPORT; OCULOMOTOR FUNCTIONS; INTERMEDIATE GRAY; DEEP LAYERS; GUINEA-PIG; CAT;
Keywords:
DEVELOPMENT; PERIAQUEDUCTAL GRAY MATTER; NEUROHUMORAL INTERACTIONS; CAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Graybiel e R.B. Illing, "ENKEPHALIN-POSITIVE AND ACETYLCHOLINESTERASE-POSITIVE PATCH SYSTEMS IN THE SUPERIOR COLLICULUS HAVE MATCHING DISTRIBUTIONS BUT DISTINCT DEVELOPMENTAL HISTORIES", Journal of comparative neurology, 340(3), 1994, pp. 297-310

Abstract

Histochemical stains for acetylcholinesterase activity and enkephalin-like immunoreactivity both demonstrate a high degree of patterning inthe superior colliculus, particularly in the intermediate and deep layers. Both markers occur predominantly in the neuropil of these layers, and both are principally distributed in distinct macroscopic compartments. We report here that patches of heightened acetylcholinesterase activity correspond to patches of high enkephalin-like immunoreactivity. The two markers thus delineate largely the same domain in the intermediate and deep layers. The most prominent zones of staining for enkephalin-like peptide and for acetylcholinesterase also coincided in thedorsolateral periaqueductal gray matter. These findings suggest a close interlocking of one or more acetylcholinesterase-containing systemswith one or more pathways related to endogenous opioids in the superior colliculus. As the acetylcholinesterase expression in the patches is known to match in detail choline acetyltransferase expression, our results also suggest the possibility of local cholinergic-opiatergic interactions. In some sections, blood vessels associated with enkephalin-rich and acetylcholinesterase-rich patches extended beyond the colliculus into the periaqueductal gray matter, where they again became surrounded by dense fibrous labelling. This pattern suggests that neurohumoral signal exchange might occur through blood vessels even in a sensory-motor structure such as the colliculus. In a postnatal developmental series of kitten brains we found that enkephalin-like immunoreactivity was already distinctly compartmental in the intermediate layers at birth and continued to show this distribution throughout postnatal development. By contrast, acetylcholinesterase staining was nearly homogeneous at birth and became compartmental gradually during the first postnatal weeks. Thus, despite the eventual near coincidence of the enkephalin-rich and acetylcholinesterase-rich compartments of the superior colliculus, they mark systems that follow distinct programs of neurochemical development. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:02:17