Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
REGIONAL INTRAARTERIAL INFUSION OF METHOTREXATE WITH LEUCOVORIN RESCUE IN A RAT-TUMOR MODEL
Autore:
POLOGEORGIS G; AGNANTIS N; KOTTARIDIS S;
Indirizzi:
59 YPSILANTOU ST GR-11521 ATHENS GREECE ST SAVAS HOSP,HELLEN ANTICANC INST,DEPT SURG GR-11522 ATHENS GREECE ST SAVAS HOSP,HELLEN ANTICANC INST,DEPT PATHOL GR-11522 ATHENS GREECE ST SAVAS HOSP,HELLEN ANTICANC INST,INST GEORGE PAPANIKOLAOU GR-11522 ATHENS GREECE
Titolo Testata:
Anticancer research
fascicolo: 6A, volume: 13, anno: 1993,
pagine: 2193 - 2199
SICI:
0250-7005(1993)13:6A<2193:RIIOMW>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHARMACOKINETICS;
Keywords:
WALKER 252 CARCINOSARCOMA; METHOTREXATE; LEUCOVORIN RESCUE; REGIONAL INTRAARTERIAL CHEMOTHERAPY; INFLOW OCCLUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
G. Pologeorgis et al., "REGIONAL INTRAARTERIAL INFUSION OF METHOTREXATE WITH LEUCOVORIN RESCUE IN A RAT-TUMOR MODEL", Anticancer research, 13(6A), 1993, pp. 2193-2199

Abstract

Walker 2S6 carcinosarcoma was transplanted in the paw of 52 male Wistar mts. A week later, the animals were divided into 6 separate groups and treated in different ways, as follows. Group I (control): no treatment. Group II: femoral artery ligation (FAL). Group III: ligation-intraarterial chemotherapy (LIC) with methotrexate (MTX). Group IV: the same treatment followed by leucovorin rescue (LIC + RES). Group V: tourniquet intraarterial chemotherapy and rescue (TIC + RES). Group VI: the same treatment applied via the iliac artery (iliac TIC + RES). The best results (primary tumor eradication: 8/10 cases, propagation of thetumor to the inguinal region: 4/10 cases, necroses of the distal partof the paw: 0/10 cases, p > 0.05) were observed in group VI, where iliac LIC + RES was performed Analysis of the treatment's mechanism of action revealed that there is an area of optimal treatment in the middle of the limb, and two peripheral zones of under-treatment. At the proximal zone (inguinal region) propagation of the tumor can occur, whereas at the distal zone necrosis of the paw can be manifested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 10:29:24