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Titolo:
L-HISTIDINOL INCREASES THE VULNERABILITY OF CULTURED HUMAN LEUKEMIA AND LYMPHOMA-CELLS TO ANTICANCER DRUGS
Autore:
WARRINGTON RC; CHENG I; ZHANG L; FANG WD;
Indirizzi:
UNIV SASKATCHEWAN,DEPT BIOCHEM SASKATOON S7N 0W0 SK CANADA UNIV SASKATCHEWAN,CANC RES UNIT SASKATOON S7N 0W0 SK CANADA
Titolo Testata:
Anticancer research
fascicolo: 6A, volume: 13, anno: 1993,
pagine: 2107 - 2112
SICI:
0250-7005(1993)13:6A<2107:LITVOC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL CANCER-CHEMOTHERAPY; MULTIDRUG-RESISTANT PHENOTYPE; PROTEIN-SYNTHESIS; MICE; 5-FLUOROURACIL; EFFICACY; B16F10-MELANOMA; PROLIFERATION; SELECTIVITY; COMBINATION;
Keywords:
L-HISTIDINOL; ANTICANCER AGENTS; LEUKEMIA CELLS; LYMPHOMA CELLS; HUMAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
R.C. Warrington et al., "L-HISTIDINOL INCREASES THE VULNERABILITY OF CULTURED HUMAN LEUKEMIA AND LYMPHOMA-CELLS TO ANTICANCER DRUGS", Anticancer research, 13(6A), 1993, pp. 2107-2112

Abstract

L-Histidinol, a structural analogue of the essential amino acid L-histidine, enhances the toxicity of a variety of anticancer drugs for many tumor cells of animal origin. In this study, the effects of L-histidinol on the proliferation and anticancer drug susceptibility of two human tumor cell lines of lymphoid origin, Daudi and MOLT 4, have been examined. L-Histidinol increased the inherent capacity of six differentantineoplastic agents to kill these human tumor cells, in a dose- andtime- dependent manner; in spite of the observation that it slowed cell cycle progression in both lines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:44:54