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Titolo:
EFFECT OF TUMOR-GROWTH ON THE MACROPHAGE RESPONSE TO THE ANTITUMOR AGENT 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID
Autore:
CHING LM; JOSEPH WR; BAGULEY BC;
Indirizzi:
UNIV AUCKLAND,SCH MED,CANC RES LAB,PRIVATE BAG 92019 AUCKLAND NEW ZEALAND
Titolo Testata:
Anticancer research
fascicolo: 6A, volume: 13, anno: 1993,
pagine: 2069 - 2075
SICI:
0250-7005(1993)13:6A<2069:EOTOTM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLAVONE ACETIC-ACID; KILLER CELL-ACTIVITY; MURINE RENAL-CANCER; FLAVONE-8-ACETIC ACID; NECROSIS-FACTOR; XANTHENONE-4-ACETIC ACID; COLON-38 TUMORS; MICE; ENDOTOXIN; NSC-347512;
Keywords:
MACROPHAGE; HEMORRHAGIC NECROSIS; MAMMARY M-16/C; TUMOR; LIPOPOLYSACCHARIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
L.M. Ching et al., "EFFECT OF TUMOR-GROWTH ON THE MACROPHAGE RESPONSE TO THE ANTITUMOR AGENT 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID", Anticancer research, 13(6A), 1993, pp. 2069-2075

Abstract

Peritoneal macrophages from C3H/HeN mice bearing subcutaneous M-16/C or Spon-2 mammary carcinomas had enhanced tumouricidal activity over control macrophages from non-tumour bearers in response to 5,6-dimethylxanthenone-4-acetic acid (5,6-MeXAA), a novel antitumour agent which has been scheduled for clinical evaluation. palpable M-16/C tumour growing in C3H/HeN mice was similar to that of Bacillus Calmette-Guerin (BCG) infection, with macrophages being fully activated and tumouricidalwithout any further stimulus being required in culture. Macrophages from Spon-2 tumour bearing mice behaved like ''primed'' thioglycollate-elicited macrophages and produced a tumouricidal response to 5,6-MeXXAwhich was significantly higher than that obtained from resident peritoneal macrophages from non-tumour bearing mice. Resident and thioglycollate-elicited macrophages from C3H/HeJ mice were hyporesponsive not only to lipopolysaccharide (LPS), but to 5,6-MeXAA as well. Hyporesponsiveness was abrogated by BCG infection or by the presence of the M-16/C tumour, but not by the presence of the Spon-2 tumour. In response toLPS at low concentrations, or to 5, 6-MeXAA at all concentrations, tumouricidal activity from macrophages from Spon-2-bearing C3H/HeJ mice was severely depressed compared with activity from their C3H/HeN counterparts. However, 5,6-MeXAA induced similar levels of haemorrhagic necrosis of tumours implanted in either C3H/HeJ or C3H/HeN hosts. LPS-induced haemorrhagic necrosis was significantly lower in C3H/HeJ than in C3H/HeN hosts. The results show that the presence of subcutaneous tumours modulates the activity of peritoneal macrophages in mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 15:08:44