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Titolo:
A SMALL ELEMENT FROM THE MASON-PFIZER MONKEY VIRUS GENOME MAKES HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 EXPRESSION AND REPLICATION REV-INDEPENDENT
Autore:
BRAY M; PRASAD S; DUBAY JW; HUNTER E; JEANG KT; REKOSH D; HAMMARSKJOLD ML;
Indirizzi:
UNIV VIRGINIA,MYLES H THALER CTR AIDS & HUMAN RETROVIRUS RES CHARLOTTESVILLE VA 22908 UNIV VIRGINIA,MYLES H THALER CTR AIDS & HUMAN RETROVIRUS RES CHARLOTTESVILLE VA 22908 UNIV VIRGINIA,DEPT MICROBIOL CHARLOTTESVILLE VA 22908 UNIV ALABAMA,DEPT MICROBIOL BIRMINGHAM AL 35294 NIAID,MOLEC MICROBIOL LAB BETHESDA MD 20892 SUNY BUFFALO BUFFALO NY 00000
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 4, volume: 91, anno: 1994,
pagine: 1256 - 1260
SICI:
0027-8424(1994)91:4<1256:ASEFTM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATE REPLACEMENT VECTOR; MESSENGER-RNA; HIV-1 REV; NUCLEOTIDE-SEQUENCE; GENE-PRODUCT; PROTEIN; RETROVIRUS; ENV; BINDING; INVITRO;
Keywords:
RNA TRANSPORT; NUCLEAR EXPORT; RETROVIRAL GENE EXPRESSION; CIS-ACTING RNA ELEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M. Bray et al., "A SMALL ELEMENT FROM THE MASON-PFIZER MONKEY VIRUS GENOME MAKES HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 EXPRESSION AND REPLICATION REV-INDEPENDENT", Proceedings of the National Academy of Sciences of the United Statesof America, 91(4), 1994, pp. 1256-1260

Abstract

Replication of human immunodeficiency virus type 1 (HIV-1) is dependent on the viral Rev protein. This protein acts in concert with the cis-acting rev-responsive element present in intron-containing RNAs to facilitate nuclear export of these RNAs. Here we show that a cis-acting 219-nucleotide sequence from an unrelated ''simple'' retrovirus, Mason-Pfizer monkey virus (MPMV), enables Rev-independent HIV-1 replication. This sequence is present in an untranslated region near the 3' end of the MPMV genome. The MPMV element is also able to efficiently substitute for Rev in expression of Gag/Pol and Env proteins from subgenomicconstructs. We hypothesize that the MPMV element functions by interacting with a cellular factor that plays a role in mRNA transport analogous to that of the Rev protein. It might be possible to exploit this element in the development of an HIV vaccine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:19:53