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Titolo:
SYNTHESIS OF TRITIATED N1'-ALKYL DERIVATIVES OF THE DELTA-OPIOID RECEPTOR-LIGAND NALTRINDOLE
Autore:
LEVER JR; JOHNSON SM;
Indirizzi:
JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT ENVIRONM HLTH SCI,615 N WOLFE ST BALTIMORE MD 21205
Titolo Testata:
Journal of labelled compounds & radiopharmaceuticals
fascicolo: 2, volume: 39, anno: 1997,
pagine: 115 - 122
SICI:
0362-4803(1997)39:2<115:SOTNDO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Keywords:
NALTRINDOLE; TRITIUM; DELTA OPIOID RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Lever e S.M. Johnson, "SYNTHESIS OF TRITIATED N1'-ALKYL DERIVATIVES OF THE DELTA-OPIOID RECEPTOR-LIGAND NALTRINDOLE", Journal of labelled compounds & radiopharmaceuticals, 39(2), 1997, pp. 115-122

Abstract

Tritiated N1'-methyI and N1'-ethyl analogues of naltrindole (NTI) have been synthesized for evaluation as radioligands for studies of deltaopioid receptors. The two N1'-alkyl-5',7'-dibromoNTI precursors for radiolabeling were prepared by base-promoted alkylation of 2,4-dibromophenylhydrazine with either iodomethane or iodoethane followed by condensation with naltrexone using the Fischer indole synthesis. Catalytic debromotritiation followed by HPLC purification afforded [H-3]MeNTI (17.3 Ci/mmol) and [H-3]EtNTI (22.5 Ci/mmol)with high chemical and radiochemical purities (greater than or equal to 99.8%).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:26:43