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Titolo:
DEVELOPMENT AND PROLIFERATION OF LYMPHOCYTES IN MICE DEFICIENT FOR BOTH INTERLEUKIN-2 AND INTERLEUKIN-4
Autore:
SADLACK B; KUHN R; SCHORLE H; RAJEWSKY K; MULLER W; HORAK I;
Indirizzi:
UNIV WURZBURG,INST VIROL & IMMUNOBIOL,VERSBACHER STR 7 D-97078 WURZBURG GERMANY UNIV WURZBURG,INST VIROL & IMMUNOBIOL D-97078 WURZBURG GERMANY UNIV COLOGNE,INST GENET COLOGNE GERMANY
Titolo Testata:
European Journal of Immunology
fascicolo: 1, volume: 24, anno: 1994,
pagine: 281 - 284
SICI:
0014-2980(1994)24:1<281:DAPOLI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMBRYONIC STEM-CELLS; IMMUNE-RESPONSE; HPRT GENE; LYMPHOKINES; SELECTION; THYMUS;
Keywords:
INTERLEUKIN-2; INTERLEUKIN-4; DEVELOPMENT AND PROLIFERATION OF LYMPHOCYTES; CYTOKINES; KNOCK-OUT MICE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
B. Sadlack et al., "DEVELOPMENT AND PROLIFERATION OF LYMPHOCYTES IN MICE DEFICIENT FOR BOTH INTERLEUKIN-2 AND INTERLEUKIN-4", European Journal of Immunology, 24(1), 1994, pp. 281-284

Abstract

Interleukin (IL)-2 and IL-4 are considered as important regulators ofgrowth and differentiation of lymphocytes. We report that in mice made deficient for both IL-2 and IL-4 by gene targeting all major T cell subsets and B cells were normal, indicating that IL-2 and IL-4 are notessential for development of the immune system. Paradoxically, proliferation of T cells was increased in both IL-2- and IL-4-deficient homozygous mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:50:03