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Titolo:
ULTRASTRUCTURAL ANALYSIS OF THYMIC NURSE CELL EPITHELIUM
Autore:
PENNINGER J; RIEKER T; ROMANI N; KLIMA J; SALVENMOSER W; DIETRICH H; STOSSEL H; WICK G;
Indirizzi:
INNSBRUCK UNIV,SCH MED,INST GEN & EXPTL PATHOL,FRITZ PREGL STR 3 A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV,SCH MED,INST GEN & EXPTL PATHOL A-6020 INNSBRUCK AUSTRIA ONTARIO CANC INST TORONTO M4X 1K9 ON CANADA INNSBRUCK UNIV,DEPT DERMATOL A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV,INST ZOOL A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV,FAC NAT SCI,DIV ULTRASTRUCT SCI & EVOLUT BIOL INNSBRUCK AUSTRIA
Titolo Testata:
European Journal of Immunology
fascicolo: 1, volume: 24, anno: 1994,
pagine: 222 - 228
SICI:
0014-2980(1994)24:1<222:UAOTNC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; EPIDERMAL LANGERHANS CELLS; VERSUS-HOST REACTION; CLASS-II MOLECULES; POSITIVE SELECTION; ANTIGEN PRESENTATION; TRANSGENIC MICE; T-CELLS; LYMPHOCYTES; TOLERANCE;
Keywords:
ANTIGEN PROCESSING; ACIDIC ORGANELLES; T CELL SELECTION; THYMIC MICROENVIRONMENT; THYMIC NURSE CELL; THYMIC EPITHELIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
J. Penninger et al., "ULTRASTRUCTURAL ANALYSIS OF THYMIC NURSE CELL EPITHELIUM", European Journal of Immunology, 24(1), 1994, pp. 222-228

Abstract

Thymic nurse cells (TNC), a paradigmatic cell type of cortical epithelium, are large lymphoid-epithelial cell complexes of thymocytes enclosed within vacuoles lined by the epithelial cell membrane. TNC expressmajor histocompatibility complex (MHC) class I and class II moleculeson their surface and vacuole-lining membranes at high density and it was suggested that TNC provide an optimal microenvironment for positive selection of T cells. In this report we present electron microscopical data demonstrating that chicken TNC display morphological structures of exocytosis previously shown for hormone-secreting cells. In TNC, however, exocytosis is restricted to the capillary cleft between the epithelial cell and engulfed thymocytes. Thus, besides physical contactbetween the epithelial cell and enclosed thymocytes, TNC may additionally influence the development of thymocytes through release of soluble factors in a restricted microenvironment. By employing the 3-(2,4-dinitroanilino)-3'-amino-N-methyl propylamine technique which at the ultrastructural level detects acidic organelles involved in processing ofantigens presented by MHC class II molecules,we also show that TNC contain acidic compartments similar to classical antigen-presenting cells, i.e. early and late endosomes and lysosomes, albeit in a lower amount than in thymic dendritic cells. This fact provides evidence that TNC not only are capable of antigen presentation but also possess the intracellular machinery for antigen processing.

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Documento generato il 29/11/20 alle ore 05:53:30