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Titolo:
DOES DOPAMINE EXERT A TONIC INHIBITORY CONTROL ON THE RELEASE OF STRIATAL ACETYLCHOLINE IN-VIVO
Autore:
IMPERATO A; OBINU MC; DAZZI L; GESSA GL;
Indirizzi:
UNIV CAGLIARI,BERNARD B BRODIE DEPT NEUROSCI,VIA PORCELL 4 I-09124 CAGLIARI ITALY UNIV CAGLIARI,BERNARDO LODDO DEPT EXPTL BIOL I-09124 CAGLIARI ITALY
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 251, anno: 1994,
pagine: 271 - 279
SICI:
0014-2999(1994)251:2-3<271:DDEATI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; ENDOGENOUS DOPAMINE; RECEPTOR AGONISTS; PHARMACOLOGICAL PROFILE; INTRACEREBRAL DIALYSIS; INVIVO RELEASE; D-1; STIMULATION; NEURONS; NEUROLEPTICS;
Keywords:
ACETYLCHOLINE RELEASE; DOPAMINE D-1 RECEPTOR; DOPAMINE D-2 RECEPTOR; RESERPINE; ALPHA-METHYL-TYROSINE; LY 171555; DOPAMINE D-1 RECEPTOR ANTAGONIST; DOPAMINE D-2 RECEPTOR BLOCKER; SCH 23390;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
A. Imperato et al., "DOES DOPAMINE EXERT A TONIC INHIBITORY CONTROL ON THE RELEASE OF STRIATAL ACETYLCHOLINE IN-VIVO", European journal of pharmacology, 251(2-3), 1994, pp. 271-279

Abstract

The role of dopamine transmission on striatal acetylcholine release was investigated by using brain microdialysis. Blockade of dopamine D-2receptors with(-)-sulpiride or haloperidol increased acetylcholine release to a maximum of 80% (after 50 and 0.5 mg/kg, respectively). Thiseffect was prevented by blockade of dopamine D-1 receptors with 0.5 mg/kg SCH 39166 or 0.1 mg/kg SCH 23390, or by depletion of dopamine stores after 5 mg/kg reserpine + 150 mg/kg alpha-methyltyrosine. Treatment with SCH 39166, SCH 23390 or reserpine + alpha-methyltyrosine reduced acetylcholine release by about a maximum of 30%. Stimulation of dopamine D-2 receptors with LY 171555 (quinpirole) at a low, sedative dose(0.05 mg/kg) reduced acetylcholine release by about 30% with no further reduction at higher doses up to 1 mg/kg. Moreover, LY 171555 (0.1 mg/kg) given to SCH 39166 (0.5 mg/kg)- or SKF 38393 (20 mg/kg)-pretreated rats did not decrease acetylcholine release, suggesting that its effect is through a dopamine D-1 receptor-mediated mechanism. In contrast, in dopamine-depleted rats, LY 171555 0.1 mg/kg became more effective in decreasing acetylcholine release (about 70%) also after SCH 39166(0.5 mg/kg) pretreatment (about 80%), thus acting independently of dopamine D-1 receptor mechanisms. These results indicate that, in normalcircumstances, endogenous dopamine facilitates striatal acetylcholinerelease through dopamine D-1 receptors. The results argue against thecommonly accepted view that dopamine D-2 receptors exert a tonic inhibitory control on acetylcholine release. Moreover, they suggest that dopamine D-2 receptors, in circumstances of dopamine depletion, may exert an inhibitory control on acetylcholine release independent of dopamine D-1 receptor mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:28:04