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Titolo:
RELATIONSHIPS BETWEEN MONOAMINERGIC AND CHOLINERGIC INNERVATION OF THE RAT THYMUS DURING AGING
Autore:
MICIC M; LEPOSAVIC G; UGRESIC N;
Indirizzi:
IMMUNOL RES CTR,VOJVODE STEPE 458 YU-11221 BELGRADE YUGOSLAVIA FAC PHARM BELGRADE BELGRADE YUGOSLAVIA
Titolo Testata:
Journal of neuroimmunology
fascicolo: 1-2, volume: 49, anno: 1994,
pagine: 205 - 212
SICI:
0165-5728(1994)49:1-2<205:RBMACI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC INNERVATION; PARASYMPATHETIC INNERVATION; MURINE THYMUS; CELLS; ACETYLCHOLINESTERASE; HISTOFLUORESCENCE; LYMPHOPOIESIS; HORMONES; ONTOGENY; PEPTIDE;
Keywords:
RAT THYMUS; MONOAMINE CONCENTRATION; ACETYLCHOLINESTERASE ACTIVITY; AGING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M. Micic et al., "RELATIONSHIPS BETWEEN MONOAMINERGIC AND CHOLINERGIC INNERVATION OF THE RAT THYMUS DURING AGING", Journal of neuroimmunology, 49(1-2), 1994, pp. 205-212

Abstract

The present study has been undertaken in order to investigate whetheraging is accompanied by alterations in the thymic autonomic innervation. The results showed that in aged rats compared to young adult rats the density of monoaminergic histofluorescent nerve profiles decreasedremarkably, while their pattern of intrathymic distribution remained unchanged. The thymic concentrations of noradrenaline (NA) and dopamine (DA) also significantly decreased between the age of 12 and 18 months. However, the density of thymic autofluorescent cells (afc) markedlyincreased over the same period, as well as the concentration of 5-hydroxytryptamine (5-HT). The aged rat thymus seemed to be able to maintain its cholinergic innervation in terms of density and pattern of distribution, while the density of cells with intracytoplasmic acetylcholinesterase (AChE) staining even increased. The neurochemical measurement showed an increase in the activity of AChE between the age of 9 to 18 months. The results indicate an altered relation between the components of thymic autonomic innervation of aged rats that might be relatedto the reduced immunocompetence of their T cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:10:24