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Titolo:
THE EFFECT OF THE CHOLECYSTOKININ ANTAGONIST DEVAZEPIDE (L364718) ON THE ILEAL BRAKE MECHANISM IN THE RAT
Autore:
BROWN NJ; RUMSEY RDE; READ NW;
Indirizzi:
UNIV SHEFFIELD,ROYAL HALLAMSHIRE HOSP,DEPT SURG & ANAESTHET SCI,FLOORK SHEFFIELD S10 2JF ENGLAND UNIV SHEFFIELD,DEPT BIOMED SCI SHEFFIELD S10 2TN ENGLAND
Titolo Testata:
Journal of Pharmacy and Pharmacology
fascicolo: 12, volume: 45, anno: 1993,
pagine: 1033 - 1036
SICI:
0022-3573(1993)45:12<1033:TEOTCA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIT-TIME; PEPTIDE-YY; RECEPTOR ANTAGONIST; INTESTINAL TRANSIT; L-364,718; STOMACH; POTENT; CCK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
N.J. Brown et al., "THE EFFECT OF THE CHOLECYSTOKININ ANTAGONIST DEVAZEPIDE (L364718) ON THE ILEAL BRAKE MECHANISM IN THE RAT", Journal of Pharmacy and Pharmacology, 45(12), 1993, pp. 1033-1036

Abstract

Studies were carried out on 28 male adult rats to investigate whetherthe selective cholecystokinin-receptor antagonist devazepide influences gastrointestinal transit under control conditions and when it is delayed by ileal infusion of lipid. Stomach-to-caecum transit time of the head of the test meal was measured using environmental hydrogen analysis and the distribution of the meal was assessed using the radiolabelled meal technique. Oral administration of devazepide (4 mg kg(-1)) had no significant effect on transit time of the head of the baked beantest meal under control conditions, but significantly reversed the delay in transit time induced by ileal infusion of lipid (P<0.01). Studying the distribution of the meal showed that Intralipid delayed transit time by delaying both gastric emptying (P<0.01) and small bowel transit (P<0.05). Devazepide did not alter the control distribution of themeal during ileal saline infusion, but during ileal infusion of lipid, devazepide further delayed gastric emptying (P<0.01); the geometric centre of the meal was situated more proximally in the gastrointestinal tract (P<0.05), but there was more of the meal in the colon (P<0.01). The latter is compatible with the early rise in environmental hydrogen during devazepide administration and ileal lipid infusion and suggests that peripheral cholecystokinin receptors may modulate or mediate the delay in small bowel transit induced by ileal lipid. However, the data also suggest that mechanisms other than those involving cholecystokinin play a dominant role in the regulation of postprandial and lipid-delayed gastric emptying of a meal.

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Documento generato il 30/11/20 alle ore 16:30:42