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Titolo:
GENDER AND THE EFFECT OF GONADAL-HORMONES ON THE PROGRESSION OF INHERITED POLYCYSTIC KIDNEY-DISEASE IN RATS
Autore:
COWLEY BD; RUPP JC; MUESSEL MJ; GATTONE VH;
Indirizzi:
UNIV KANSAS,MED CTR,DEPT ANAT & CELL BIOL,3901 RAINBOW BLVD KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT ANAT & CELL BIOL KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT MED KANSAS CITY KS 66103 UNIV KANSAS,MED CTR,DEPT BIOCHEM & MOL BIOL KANSAS CITY KS 66103
Titolo Testata:
American journal of kidney diseases
fascicolo: 2, volume: 29, anno: 1997,
pagine: 265 - 272
SICI:
0272-6386(1997)29:2<265:GATEOG>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; ACQUIRED CYSTIC-DISEASE; HAN-SPRD RATS; GENE-EXPRESSION; RENAL-FAILURE; FACTOR-I; SEX; AGE; DETERMINANT; DEPENDENCE;
Keywords:
TESTOSTERONE; POLYCYSTIC KIDNEY DISEASE; RAT; GENDER; AZOTEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
B.D. Cowley et al., "GENDER AND THE EFFECT OF GONADAL-HORMONES ON THE PROGRESSION OF INHERITED POLYCYSTIC KIDNEY-DISEASE IN RATS", American journal of kidney diseases, 29(2), 1997, pp. 265-272

Abstract

Human autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disease and displays a gender dimorphism in renal disease progression, Han:SPRD-Cy rats manifest a form of ADPKD that is similarin many respects to that seen in humans, In Han:SPRD rats, male Cy/+ rats have more prominent renal changes and develop renal failure at anearly age, whereas female Cy/+ rats exhibit less severe renal cystic change and have normal renal function until advanced age. To determinewhether the male gonadal hormone, testosterone, contributes to this gender dimorphism, males were sham operated or castrated; some castrated rats were repleted with Sn-dihydrotestosterone. Female rats were sham operated or ovariectomized before sham operation or testosterone treatment, All treatments started at 4 weeks of age and ended at 10 weeksof age. Renal enlargement, cystic change, and renal function were assessed. In the males, castration reduced renal enlargement and cystic change; testosterone treatment abrogated these effects, Neither of these manipulations affected azotemia in male Cy/+ rats, In the females, testosterone was renotropic for both normal and cystic kidneys. In the Cy/+ females, testosterone treatment caused azotemia and an increase in the severity of the PKD. Ovariectomy blunted the effect of testosterone on cystic kidney enlargement. Testosterone treatment did not completely erase the gender-associated differences in azotemia in the Cy/+ rat, These data confirm the renotropic effects of testosterone and indicate that testosterone influences the progression of renal cystic change in male and female rats with ADPKD. (C) 1997 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:32:22