Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TOLUENE EXPOSURE AFFECTS THE FUNCTIONAL-ACTIVITY OF THE OUTER HAIR-CELLS
Autore:
JOHNSON AC; CANLON B;
Indirizzi:
NATL INST OCCUPAT HLTH,DEPT NEUROMED S-17184 SOLNA SWEDEN KAROLINSKA INST,DEPT PHYSIOL & PHARMACOL S-17177 STOCKHOLM SWEDEN
Titolo Testata:
Hearing research
fascicolo: 1-2, volume: 72, anno: 1994,
pagine: 189 - 196
SICI:
0378-5955(1994)72:1-2<189:TEATFO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC-DISTORTION PRODUCTS; 2F1-F2 OTOACOUSTIC EMISSIONS; 2 DISCRETE SOURCES; HEARING-LOSS; COCHLEAR MECHANICS; AUDITORY-SENSITIVITY; GUINEA-PIGS; MUTANT MICE; RATS; NOISE;
Keywords:
AUDITORY BRAIN-STEM RESPONSE; COCHLEA; DISTORTION PRODUCT OTOACOUSTIC EMISSIONS; RATS; SOLVENT; HAIR CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
A.C. Johnson e B. Canlon, "TOLUENE EXPOSURE AFFECTS THE FUNCTIONAL-ACTIVITY OF THE OUTER HAIR-CELLS", Hearing research, 72(1-2), 1994, pp. 189-196

Abstract

Rats were exposed to toluene by inhalation (1400 ppm, 16 h/d, 8 days)and the auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOEs) were used as measures of the auditory sensitivity. These measurements were made before the exposure to toluene, 3 and 5 days after the start of the exposure and 4 days after the end ofthe exposure. To quantify the repeated DPOE data the area under the curve of the DPOE amplitudes versus the stimuli levels was calculated and used for statistical analysis. Results demonstrate that 3 days of toluene exposure tended to lower DPOE amplitudes and elevate ABR thresholds. Similarly after 5 days of exposure significantly lower DPOE amplitudes were observed at most frequencies along with elevated ABR thresholds. At 4 days post-exposure DPOE amplitudes were greatly diminishedat all frequencies and the ABR thresholds were raised by about 40 dB between 1.6 and 20 kHz. These results show a parallel shift between ABR thresholds and DPOE amplitudes during toluene exposure. Furthermore,the results from the DPOE measurements indicate that mainly the outerhair cells are adversely affected by toluene exposure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:35:50