Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PRODUCTION OF INTERLEUKIN-2 BY EL4 TUMOR-CELLS INDUCES NATURAL-KILLERCELL-MEDIATED AND T-CELL-MEDIATED IMMUNITY
Autore:
VISSEREN MJW; KOOT M; VANDERVOORT EIH; GRAVESTEIN LA; SCHOENMAKERS HJ; KAST WM; ZIJLSTRA M; MELIEF CJM;
Indirizzi:
UNIV HOSP LEIDEN,DEPT IMMUNOHAEMATOL & BLOOD BANK,BLD 1,E3 Q,POB 96002300 RC LEIDEN NETHERLANDS ACAD HOSP LEIDEN,DEPT IMMUNOHAEMATOL & BLOOD BANK LEIDEN NETHERLANDS NETHERLANDS CANC INST,DEPT IMMUNOL AMSTERDAM NETHERLANDS
Titolo Testata:
Journal of immunotherapy with emphasis on tumor immunology
fascicolo: 2, volume: 15, anno: 1994,
pagine: 119 - 128
SICI:
1067-5582(1994)15:2<119:POIBET>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSE RECOMBINANT INTERLEUKIN-2; CYTOLYTIC LYMPHOCYTES-T; GROWTH-FACTOR; MONOCLONAL-ANTIBODY; ADHESION MOLECULES; GENE-TRANSFER; BEARING MICE; NECK-CANCER; INVIVO; IMMUNOTHERAPY;
Keywords:
TUMOR; INTERLEUKIN-2; NATURAL KILLER CELLS; CYTOTOXIC T-LYMPHOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
M.J.W. Visseren et al., "PRODUCTION OF INTERLEUKIN-2 BY EL4 TUMOR-CELLS INDUCES NATURAL-KILLERCELL-MEDIATED AND T-CELL-MEDIATED IMMUNITY", Journal of immunotherapy with emphasis on tumor immunology, 15(2), 1994, pp. 119-128

Abstract

Systemic administration of recombinant interleukin (rIL)-2 to cancer patients has met with limited clinical success since, despite significant antitumor effects, its use is associated with severe toxicity. Local production of IL-2 by IL-2 gene transfected tumor cells in murine model systems has been reported to induce specific immunity-devoid of toxicity-to the parental non-IL-2-producing tumor cells. We now report enhanced resistance in nonimmunized mice to murine EL4 thymoma cells, producing murine IL-2 following gene transfer (EL4pIL-2). This effect is mediated by activated natural killer (NK) cells, since we observed the same effect in nude mice but not in NK-depleted mice. Additionally, in mice repeatedly vaccinated with irradiated EL4pIL-2 cells, we observed immunity to challenge with a tumorigenic dose of EL4 cells transfected with a control vector, EL4p. EL4-specific cytotoxic T-lymphocytes (CTLs) were detected in these mice. Mice vaccinated with irradiatedEL4p cells were less protected against challenge with a tumorigenic dose of EL4p cells. This study indicates that although some IL-2-producing autologous tumor cells elicit NK-mediated responses and not CTL responses upon inoculation, tumor-specific CTL responses are generated upon repeated vaccinations with these cells. This strategy has potential application for treating a wide variety of cancer patients with autologous IL-2 producing tumor cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:06:21