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Titolo:
FIBROBLAST GROWTH FACTOR-II (FGF-2) IN THE NUCLEUS - TRANSLOCATION PROCESS AND TARGETS
Autore:
AMALRIC F; BOUCHE G; BONNET H; BRETHENOU P; ROMAN AM; TRUCHET I; QUARTO N;
Indirizzi:
CNRS,INST BIOL CELLULAIRE & GENET,BIOL MOLEC EUCARYOTE LAB,118 ROUTE NARBONNE F-31062 TOULOUSE FRANCE CNRS,INST BIOL CELLULAIRE & GENET,BIOL MOLEC EUCARYOTE LAB F-31062 TOULOUSE FRANCE
Titolo Testata:
Biochemical pharmacology
fascicolo: 1, volume: 47, anno: 1994,
pagine: 111 - 115
SICI:
0006-2952(1994)47:1<111:FGF(IT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR PRODUCTION; ENDOTHELIAL-CELLS; HEPARAN-SULFATE; DNA-SYNTHESIS; RECEPTOR; BINDING; BFGF; STIMULATION; SIGNAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
F. Amalric et al., "FIBROBLAST GROWTH FACTOR-II (FGF-2) IN THE NUCLEUS - TRANSLOCATION PROCESS AND TARGETS", Biochemical pharmacology, 47(1), 1994, pp. 111-115

Abstract

FGF-2 (basic fibroblast growth factor) was recently detected in the nucleus of a variety of cell types. The large isoforms contain a functional nuclear localization signal that allows their nuclear accumulation in producing cells, while a small amount of FGF-2 added exogenously to target cells is translocated to the nucleus in phase G1 of the cellcycle according to an unknown process. We report here using Chinese hamster ovary cell mutants bearing deficiency in heparan sulfate proteoglycans (HSPGs) synthesis that HSPGs are required for transport of exogenous FGF-2 to the nucleus. Furthermore a co-transport was suggested since an active complex containing FGF-2 and HSPGs was isolated from nuclei of treated cells. Several FGF-2 nuclear targets were described. In vivo as in vitro, it activates rDNA transcription and it binds to aspecific DNA sequence that is present in the nontranscribed spacer ofribosomal genes. In vitro, FGF-2 has a strong affinity for histone H1and it activates the protein kinase CKII. In the nucleus FGF-2 could regulate gene expression through modulation of chromatin structure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:25:05